Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) abiEi-abiEii/AbiEii-AbiEi
Location 1831350..1832782 Replicon chromosome
Accession NZ_CP030124
Organism Streptococcus suis strain SH1510

Toxin (Protein)


Gene name abiEi Uniprot ID A0A0Z8TB64
Locus tag DP111_RS09280 Protein ID WP_024394846.1
Coordinates 1831937..1832782 (+) Length 282 a.a.

Antitoxin (Protein)


Gene name abiEii Uniprot ID A0A0Z8SSH7
Locus tag DP111_RS09275 Protein ID WP_002935109.1
Coordinates 1831350..1831940 (+) Length 197 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DP111_RS09245 1826468..1828618 - 2151 WP_002935100.1 peptide cleavage/export ABC transporter -
DP111_RS09250 1828821..1829012 - 192 WP_002935101.1 hypothetical protein -
DP111_RS09255 1829101..1829433 - 333 WP_114876559.1 DUF3884 family protein -
DP111_RS09260 1829402..1830718 - 1317 WP_114876560.1 glycosyltransferase family 2 protein -
DP111_RS09265 1830906..1831067 - 162 WP_002935108.1 agglutinin receptor -
DP111_RS09275 1831350..1831940 + 591 WP_002935109.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
DP111_RS09280 1831937..1832782 + 846 WP_024394846.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
DP111_RS09285 1832844..1835645 - 2802 WP_043033091.1 CHAP domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - cpsI 1750752..1874815 124063


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(33-258)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(6-50)


Sequences

Toxin        


Download         Length: 282 a.a.        Molecular weight: 32466.18 Da        Isoelectric Point: 5.4404

>T107141 WP_024394846.1 NZ_CP030124:1831937-1832782 [Streptococcus suis]
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSTYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHQMTLSED
TVKQQLKEILADSEEGISFVIQSITAIKESDDYGGYRATISCQLENIKQVIHLDIATGDVVTPQPITYDYKAIFDEENFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKEDIDFIQLKNACQRTFSYRETELDFVKIIELLERFKSDP
IQNKQWQNYSKKYSYTKGISLADVLDEMIRLITVLISINSD

Download         Length: 846 bp

>T107141 NZ_CP030124:1831937-1832782 [Streptococcus suis]
ATGAATAAAGCTAAGCTAACAGCACTCTGTCATAAAATATCAAAGAATACTGGTTTAACCTTTAATTCCGTCATGACCTA
TTACTTCCTAGAAGTCATTTTGAAAAAATTAAGTCAGAGTACCTACTCAAATCACTATATCTTCAAAGGGGGGTTTCTGC
TGTCAAATGTTATCGGAGTTGAATCTCGTAGCACGGTTGATATTGATTTTTTGTTCCATCAAATGACACTCTCAGAAGAT
ACTGTGAAGCAGCAACTCAAGGAAATTTTAGCAGATTCCGAAGAAGGGATATCTTTTGTGATTCAATCAATCACAGCTAT
TAAAGAAAGTGATGACTATGGTGGCTATCGAGCAACAATTTCGTGCCAACTTGAGAATATTAAACAAGTTATCCATTTGG
ATATTGCGACAGGTGATGTTGTAACTCCTCAGCCGATTACATACGACTATAAAGCTATTTTTGATGAAGAGAATTTTCCA
ATCATTGCTTATACAATTGAAACAATTCTAGCTGAAAAACTTCAAACCATCTATTCACGTAACTTCTTGAACAGTAGAAG
CAAAGATTTTTACGATGTTTATATTCTTTCAAAACTGAAAAAAGAAGACATTGACTTCATTCAGTTGAAAAATGCCTGTC
AGAGAACATTTTCATATCGCGAAACAGAACTCGATTTTGTAAAGATTATTGAACTACTCGAGAGGTTCAAATCTGACCCT
ATTCAGAATAAACAATGGCAAAATTATTCAAAAAAATATAGCTATACAAAAGGGATTTCACTTGCAGATGTTCTTGATGA
GATGATTCGTCTTATAACAGTACTCATTTCTATAAATTCTGATTAA

Antitoxin


Download         Length: 197 a.a.        Molecular weight: 23299.86 Da        Isoelectric Point: 7.8482

>AT107141 WP_002935109.1 NZ_CP030124:1831350-1831940 [Streptococcus suis]
MSKKEILLEFIENHNGIITYKDCKALKIPTIYLTRLEKEGIIYRVEKGIFLTQNGDYDEYYFFQYRYPKAVFSYISALYL
QQFTDEIPQYFDVTIPRGYRFNTPPANLNIHSVSKEYSELGITLVKTPMGNEVRVYDFERIICDFVIHREKIDTELFVKT
LQHYGNYSKKNLTKLYEYATKMNTLDKVKQTLEVLV

Download         Length: 591 bp

>AT107141 NZ_CP030124:1831350-1831940 [Streptococcus suis]
ATGTCAAAAAAAGAGATTCTACTTGAATTTATAGAAAACCACAATGGCATTATCACCTATAAAGACTGTAAAGCCTTAAA
GATTCCTACAATATATTTGACAAGACTAGAAAAAGAAGGGATTATTTACCGCGTCGAAAAAGGAATTTTCCTAACCCAGA
ATGGAGACTACGACGAATACTACTTCTTTCAGTACCGTTATCCCAAGGCTGTTTTCTCTTATATCTCAGCGCTTTACCTG
CAGCAATTTACAGATGAAATTCCTCAATATTTTGACGTAACCATTCCTAGAGGCTACCGTTTTAATACTCCTCCAGCAAA
TCTGAACATTCATTCCGTTTCTAAGGAATATAGCGAACTAGGAATTACACTTGTAAAAACCCCTATGGGAAACGAAGTAA
GAGTGTATGATTTTGAACGCATTATCTGTGATTTTGTCATTCATCGAGAAAAAATAGATACTGAGCTTTTTGTCAAAACA
CTTCAACATTACGGAAACTATTCTAAAAAAAATCTTACAAAACTCTATGAATATGCGACAAAAATGAACACCTTGGACAA
GGTCAAACAAACTCTGGAGGTCCTAGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8TB64

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8SSH7

References