Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 911885..912371 Replicon chromosome
Accession NZ_CP030124
Organism Streptococcus suis strain SH1510

Toxin (Protein)


Gene name relE Uniprot ID A0A0K2E5U8
Locus tag DP111_RS04650 Protein ID WP_002935012.1
Coordinates 911885..912142 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0K2E5B0
Locus tag DP111_RS04655 Protein ID WP_002935014.1
Coordinates 912132..912371 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DP111_RS04630 907519..908589 + 1071 WP_002935006.1 tyrosine recombinase XerS -
DP111_RS04635 908659..910167 - 1509 WP_013730362.1 phosphoglucomutase -
DP111_RS04640 910243..911184 - 942 WP_002935009.1 sensor histidine kinase -
DP111_RS04645 911181..911846 - 666 WP_009909826.1 response regulator transcription factor -
DP111_RS04650 911885..912142 - 258 WP_002935012.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DP111_RS04655 912132..912371 - 240 WP_002935014.1 hypothetical protein Antitoxin
DP111_RS04660 912463..914433 - 1971 WP_114876503.1 FtsX-like permease family protein -
DP111_RS04665 914434..915186 - 753 WP_024403319.1 ABC transporter ATP-binding protein -
DP111_RS04670 915275..916003 - 729 WP_114876504.1 ABC transporter permease -
DP111_RS04675 916005..916907 - 903 WP_011922412.1 ABC transporter ATP-binding protein -
DP111_RS04680 916928..917305 - 378 WP_011922413.1 NisI/SpaI family lantibiotic immunity lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 857023..1015905 158882


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-75)

Antitoxin

Protein of unknown function DUF6290

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9849.52 Da        Isoelectric Point: 10.7134

>T107140 WP_002935012.1 NZ_CP030124:c912142-911885 [Streptococcus suis]
MSYKVILSAKAQKQIRKMDKTAASLILRYLYKHIDGCDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI

Download         Length: 258 bp

>T107140 NZ_CP030124:c912142-911885 [Streptococcus suis]
TTGAGTTATAAGGTTATTTTGTCTGCTAAGGCCCAAAAGCAAATTCGAAAGATGGATAAAACCGCTGCAAGTTTGATTTT
GCGCTATCTCTACAAGCATATTGACGGTTGCGACAACCCTAGACAATACGGAAAAGCCTTGACTGCTAATCGTTCTGGCC
AATGGCGCTATCGTATCGGCAATTACAGGGTTATCGTTAATATTGAAGATGATAAATTGATTGTGACAAGCATAAAAATG
AGAAATGGAAGTATATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8924.19 Da        Isoelectric Point: 3.9191

>AT107140 WP_002935014.1 NZ_CP030124:c912371-912132 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADVAWAEYQADLANRIEPMTLEQMAEELGIEL

Download         Length: 240 bp

>AT107140 NZ_CP030124:c912371-912132 [Streptococcus suis]
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCCCTTGAAGACGAGTACGATGCGCGTGTGGCAGACGTTGCTTGGGCAG
AATACCAAGCAGACTTGGCGAATAGAATTGAGCCGATGACATTAGAACAAATGGCTGAGGAGTTGGGCATTGAGTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K2E5U8

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E5B0

References