Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/RelE(toxin) |
Location | 911885..912371 | Replicon | chromosome |
Accession | NZ_CP030124 | ||
Organism | Streptococcus suis strain SH1510 |
Toxin (Protein)
Gene name | relE | Uniprot ID | A0A0K2E5U8 |
Locus tag | DP111_RS04650 | Protein ID | WP_002935012.1 |
Coordinates | 911885..912142 (-) | Length | 86 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | A0A0K2E5B0 |
Locus tag | DP111_RS04655 | Protein ID | WP_002935014.1 |
Coordinates | 912132..912371 (-) | Length | 80 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
DP111_RS04630 | 907519..908589 | + | 1071 | WP_002935006.1 | tyrosine recombinase XerS | - |
DP111_RS04635 | 908659..910167 | - | 1509 | WP_013730362.1 | phosphoglucomutase | - |
DP111_RS04640 | 910243..911184 | - | 942 | WP_002935009.1 | sensor histidine kinase | - |
DP111_RS04645 | 911181..911846 | - | 666 | WP_009909826.1 | response regulator transcription factor | - |
DP111_RS04650 | 911885..912142 | - | 258 | WP_002935012.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
DP111_RS04655 | 912132..912371 | - | 240 | WP_002935014.1 | hypothetical protein | Antitoxin |
DP111_RS04660 | 912463..914433 | - | 1971 | WP_114876503.1 | FtsX-like permease family protein | - |
DP111_RS04665 | 914434..915186 | - | 753 | WP_024403319.1 | ABC transporter ATP-binding protein | - |
DP111_RS04670 | 915275..916003 | - | 729 | WP_114876504.1 | ABC transporter permease | - |
DP111_RS04675 | 916005..916907 | - | 903 | WP_011922412.1 | ABC transporter ATP-binding protein | - |
DP111_RS04680 | 916928..917305 | - | 378 | WP_011922413.1 | NisI/SpaI family lantibiotic immunity lipoprotein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Integrative and Conjugative Element | - | - | 857023..1015905 | 158882 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 9849.52 Da Isoelectric Point: 10.7134
>T107140 WP_002935012.1 NZ_CP030124:c912142-911885 [Streptococcus suis]
MSYKVILSAKAQKQIRKMDKTAASLILRYLYKHIDGCDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI
MSYKVILSAKAQKQIRKMDKTAASLILRYLYKHIDGCDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI
Download Length: 258 bp
>T107140 NZ_CP030124:c912142-911885 [Streptococcus suis]
TTGAGTTATAAGGTTATTTTGTCTGCTAAGGCCCAAAAGCAAATTCGAAAGATGGATAAAACCGCTGCAAGTTTGATTTT
GCGCTATCTCTACAAGCATATTGACGGTTGCGACAACCCTAGACAATACGGAAAAGCCTTGACTGCTAATCGTTCTGGCC
AATGGCGCTATCGTATCGGCAATTACAGGGTTATCGTTAATATTGAAGATGATAAATTGATTGTGACAAGCATAAAAATG
AGAAATGGAAGTATATAA
TTGAGTTATAAGGTTATTTTGTCTGCTAAGGCCCAAAAGCAAATTCGAAAGATGGATAAAACCGCTGCAAGTTTGATTTT
GCGCTATCTCTACAAGCATATTGACGGTTGCGACAACCCTAGACAATACGGAAAAGCCTTGACTGCTAATCGTTCTGGCC
AATGGCGCTATCGTATCGGCAATTACAGGGTTATCGTTAATATTGAAGATGATAAATTGATTGTGACAAGCATAAAAATG
AGAAATGGAAGTATATAA
Antitoxin
Download Length: 80 a.a. Molecular weight: 8924.19 Da Isoelectric Point: 3.9191
>AT107140 WP_002935014.1 NZ_CP030124:c912371-912132 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADVAWAEYQADLANRIEPMTLEQMAEELGIEL
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADVAWAEYQADLANRIEPMTLEQMAEELGIEL
Download Length: 240 bp
>AT107140 NZ_CP030124:c912371-912132 [Streptococcus suis]
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCCCTTGAAGACGAGTACGATGCGCGTGTGGCAGACGTTGCTTGGGCAG
AATACCAAGCAGACTTGGCGAATAGAATTGAGCCGATGACATTAGAACAAATGGCTGAGGAGTTGGGCATTGAGTTATAA
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCCCTTGAAGACGAGTACGATGCGCGTGTGGCAGACGTTGCTTGGGCAG
AATACCAAGCAGACTTGGCGAATAGAATTGAGCCGATGACATTAGAACAAATGGCTGAGGAGTTGGGCATTGAGTTATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0K2E5U8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0K2E5B0 |