Detailed information of TA system TA107132

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4148369..4149183
• Replicon: chromosome
• Accession: NZ_CP030111
• Organism: Escherichia coli strain MCJCHV-1

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: DPQ29_RS21420
• Protein ID: WP_001054376.1
• Coordinates: 4148369..4148626 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: S1NWL7
• Locus tag: DPQ29_RS21425
• Protein ID: WP_001540600.1
• Coordinates: 4148638..4149183 (+)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DPQ29_RS21390	4143657..4144763	+	1107	WP_001774143.1	N-acetylneuraminate epimerase	-
DPQ29_RS21395	4144828..4145808	+	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
DPQ29_RS21400	4146391..4147631	-	1241	Protein_3928	helicase YjhR	-
DPQ29_RS21410	4147747..4147992	+	246	Protein_3929	GNAT family N-acetyltransferase	-
DPQ29_RS21420	4148369..4148626	+	258	WP_001054376.1	hypothetical protein	Toxin
DPQ29_RS21425	4148638..4149183	+	546	WP_001540600.1	N-acetyltransferase	Antitoxin
DPQ29_RS21430	4149239..4149985	+	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
DPQ29_RS21435	4150154..4150372	+	219	Protein_3933	hypothetical protein	-
DPQ29_RS26505	4150410..4150526	+	117	Protein_3934	VOC family protein	-
DPQ29_RS21440	4150771..4151892	+	1122	WP_000010829.1	M42 family metallopeptidase	-
DPQ29_RS21445	4151889..4152167	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
DPQ29_RS21450	4152179..4153492	+	1314	WP_000460843.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimI / fimA / fimE / fimB	4138155..4157407	19252

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T107132 WP_001054376.1 NZ_CP030111:4148369-4148626 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T107132 NZ_CP030111:4148369-4148626 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19926.87 Da
• Isoelectric Point: 6.3277

>AT107132 WP_001540600.1 NZ_CP030111:4148638-4149183 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFGKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT107132 NZ_CP030111:4148638-4149183 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCGGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: S1NWL7