107106

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 75461..76049 Replicon plasmid pDA33382-85
Accession NZ_CP030109
Organism Acinetobacter baumannii strain DA33382

Toxin (Protein)


Gene name brnT Uniprot ID A0A3G6Z3M6
Locus tag DPV67_RS19755 Protein ID WP_000438826.1
Coordinates 75461..75748 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag DPV67_RS19760 Protein ID WP_001983304.1
Coordinates 75735..76049 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DPV67_RS19730 70739..71701 - 963 WP_004746678.1 IS30 family transposase -
DPV67_RS19735 71936..72778 + 843 WP_063861121.1 OXA-58 family carbapenem-hydrolyzing class D beta-lactamase OXA-164 -
DPV67_RS19740 72869..73621 + 753 Protein_93 IS1-like element ISAba3 family transposase -
DPV67_RS19745 73749..74576 + 828 WP_000073659.1 AraC family transcriptional regulator -
DPV67_RS19750 74626..75231 + 606 WP_000447788.1 LysE family translocator -
DPV67_RS19755 75461..75748 + 288 WP_000438826.1 BrnT family toxin Toxin
DPV67_RS19760 75735..76049 + 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
DPV67_RS19765 76177..78588 + 2412 WP_000932953.1 TonB-dependent receptor ZnuD2 -
DPV67_RS19770 78893..79354 + 462 WP_000761346.1 DIP1984 family protein -
DPV67_RS19940 79677..79850 - 174 WP_001282484.1 hypothetical protein -
DPV67_RS19775 79850..80221 - 372 WP_000504218.1 hypothetical protein -
DPV67_RS19780 80493..80747 - 255 WP_001014303.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aph(3')-VIa / blaOXA-164 - 1..84678 84678


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11303.72 Da        Isoelectric Point: 6.0889

>T107106 WP_000438826.1 NZ_CP030109:75461-75748 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

>T107106 NZ_CP030109:75461-75748 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT107106 WP_001983304.1 NZ_CP030109:75735-76049 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp

>AT107106 NZ_CP030109:75735-76049 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G6Z3M6

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References