Detailed information of TA system TA107103

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1635994..1636645
• Replicon: chromosome
• Accession: NZ_CP030106
• Organism: Acinetobacter baumannii strain DA33382

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: DPV67_RS08175
• Protein ID: WP_000838146.1
• Coordinates: 1636463..1636645 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A009ITU8
• Locus tag: DPV67_RS08170
• Protein ID: WP_005070359.1
• Coordinates: 1635994..1636398 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DPV67_RS08155	1631027..1631368	-	342	WP_072292230.1	phage tail protein	-
DPV67_RS08160	1631486..1635451	-	3966	WP_004644300.1	tape measure protein	-
DPV67_RS08165	1635512..1635913	-	402	WP_000720591.1	hypothetical protein	-
DPV67_RS08170	1635994..1636398	-	405	WP_005070359.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
DPV67_RS08175	1636463..1636645	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
DPV67_RS08180	1636977..1637510	-	534	WP_001185622.1	hypothetical protein	-
DPV67_RS08185	1637554..1638483	-	930	WP_032050731.1	hypothetical protein	-
DPV67_RS08190	1638591..1638803	-	213	WP_000121166.1	hypothetical protein	-
DPV67_RS08195	1638805..1639203	-	399	WP_001132270.1	hypothetical protein	-
DPV67_RS08200	1639205..1639573	-	369	WP_072292231.1	hypothetical protein	-
DPV67_RS08205	1639545..1639949	-	405	WP_072292232.1	hypothetical protein	-
DPV67_RS08210	1639958..1640326	-	369	WP_000524231.1	hypothetical protein	-
DPV67_RS08215	1640328..1640717	-	390	WP_000008492.1	hypothetical protein	-
DPV67_RS08220	1640722..1641387	-	666	WP_000767881.1	stress-responsive nuclear envelope protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1616718..1665607	48889

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T107103 WP_000838146.1 NZ_CP030106:c1636645-1636463 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T107103 NZ_CP030106:c1636645-1636463 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGACGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
CAAACACCCAACCAAAAAGGGATTAGTAACAATCCCTCATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAGCAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14735.72 Da
• Isoelectric Point: 4.4367

>AT107103 WP_005070359.1 NZ_CP030106:c1636398-1635994 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVSVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT107103 NZ_CP030106:c1636398-1635994 [Acinetobacter baumannii]
ATGTTGTATCCAATTGCTATTGAAAGAGGTACAGACACCGAAGCCTTTGGTGTCTCCGTTCCAGATATTCCAGGGTGTTT
CAGCGCAGGCGATACATTAGAGGAAGCTATCGAGAATGTTAAAGAGGCTATTTCTGGCCACTTGGAAATCCTAGCAGAAG
ATGGAGAGGAGATTCCTTTAGCATCTGATGTCAGTAAGTTTATTGACCAAGAAGATTATAGAGGTATGATCTGGGCAGTT
ACTGAAGTTGATGTTAGCCGTTACTTAGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGATTAATTCGGAAGAT
TGATGATAATGTTGGTAAAGATAAAAGATTTAAAACTCGTTCTGCTTTTTTGGCCGCTGGTGCTGAAAAGCTACTACATG
CTTAA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: A0A009ITU8