Detailed information of TA system TA107090

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-mazE/PIN(toxin)
• Location: 3658035..3658827
• Replicon: chromosome
• Accession: NZ_CP030093
• Organism: Mycobacterium tuberculosis strain RUS_B0

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: P9WFB2
• Locus tag: DPM14_RS17930
• Protein ID: WP_003403386.1
• Coordinates: 3658035..3658472 (+)
• Length: 146 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: G0TQE0
• Locus tag: DPM14_RS17935
• Protein ID: WP_003403381.1
• Coordinates: 3658582..3658827 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DPM14_RS17905	3654498..3654671	-	174	WP_003898549.1	hypothetical protein	-
DPM14_RS17910	3654668..3655006	-	339	WP_003403405.1	PIN domain-containing protein	-
DPM14_RS17915	3654918..3655244	-	327	WP_003403401.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
DPM14_RS17920	3655307..3657670	-	2364	WP_003901895.1	arylsulfatase AtsD	-
DPM14_RS17925	3657784..3658038	+	255	WP_003911263.1	antitoxin VapB7	-
DPM14_RS17930	3658035..3658472	+	438	WP_003403386.1	type II toxin-antitoxin system VapC family toxin	Toxin
DPM14_RS17935	3658582..3658827	+	246	WP_003403381.1	ribbon-helix-helix protein, CopG family	Antitoxin
DPM14_RS17940	3658814..3659122	+	309	WP_003403376.1	type II toxin-antitoxin system PemK/MazF family toxin	-
DPM14_RS17945	3659398..3660114	+	717	WP_003403371.1	CPBP family intramembrane metalloprotease	-
DPM14_RS17950	3660190..3660345	+	156	WP_003403368.1	type II toxin-antitoxin system VapB family antitoxin	-
DPM14_RS17955	3660440..3660823	+	384	WP_003403365.1	ribonuclease VapC6	-
DPM14_RS17960	3661211..3662221	-	1011	WP_003911248.1	ABC transporter ATP-binding protein	-
DPM14_RS17965	3662302..3663807	-	1506	WP_003403360.1	carotenoid cleavage oxygenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-126)

Antitoxin

• Ribbon-helix-helix protein, CopG (2-38)

Sequences

Toxin

Protein

• Length: 146 a.a.
• Molecular weight: 15245.39 Da
• Isoelectric Point: 5.1865

>T107090 WP_003403386.1 NZ_CP030093:3658035-3658472 [Mycobacterium tuberculosis]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR

Nucleotide

• Length: 438 bp

>T107090 NZ_CP030093:3658035-3658472 [Mycobacterium tuberculosis]
ATGATAGTGCTCGACACCACCGTCCTCGTCTATGCCAAAGGCGCCGAGCATCCACTCCGCGATCCCTGCCGCGATCTCGT
CGCGGCAATCGCCGACGAACGCATCGCTGCGACCACCACCGCCGAGGTGATCCAGGAGTTCGTCCACGTACGCGCCCGCC
GGCGCGACCGCAGCGACGCCGCCGCGCTGGGCCGTGTGACTATGCCGAACTGCTCTCGCCGCTACTCACCATCAATCGAG
GCCACCTCGAAGCGCGGCCTGACGCTGTTCGAGACAACGCCAGGGCTTGAAGCCTGCGACGCGGTGCTCGCGGCGGTTGC
CGCAAGCGCCGGCGCGACCGCTCTTGTCTCGGCTGACCCGGCGTTCGCCGATCTGTCGGATGTCGTGCACGTCATTCCCG
ACGCGGCCGGGATGGTCAGCCTGCTCGGCGACCGCTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9169.01 Da
• Isoelectric Point: 4.2070

>AT107090 WP_003403381.1 NZ_CP030093:3658582-3658827 [Mycobacterium tuberculosis]
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R

Nucleotide

• Length: 246 bp

>AT107090 NZ_CP030093:3658582-3658827 [Mycobacterium tuberculosis]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA

Structures

Toxin

• AlphaFold DB: A0A7U4BSW5

Antitoxin

• AlphaFold DB: G0TQE0