Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 4570372..4571033 Replicon chromosome
Accession NZ_CP030092
Organism Massilia sp. YMA4

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag DPH57_RS19560 Protein ID WP_112939244.1
Coordinates 4570372..4570821 (-) Length 150 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag DPH57_RS19565 Protein ID WP_112939245.1
Coordinates 4570827..4571033 (-) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DPH57_RS19540 4566049..4566729 + 681 WP_112939240.1 ABC transporter ATP-binding protein -
DPH57_RS19545 4566825..4567271 - 447 WP_112939241.1 FKBP-type peptidyl-prolyl cis-trans isomerase -
DPH57_RS19550 4567400..4569271 - 1872 WP_112939242.1 potassium transporter Kup -
DPH57_RS19555 4569481..4570362 + 882 WP_112939243.1 EamA family transporter RarD -
DPH57_RS19560 4570372..4570821 - 450 WP_112939244.1 type II toxin-antitoxin system VapC family toxin Toxin
DPH57_RS19565 4570827..4571033 - 207 WP_112939245.1 DNA-binding protein Antitoxin
DPH57_RS19570 4571233..4572900 + 1668 WP_112939246.1 energy-dependent translational throttle protein EttA -
DPH57_RS19575 4573048..4573641 - 594 WP_112940820.1 outer membrane beta-barrel protein -
DPH57_RS19580 4573930..4574529 + 600 WP_175016908.1 hypothetical protein -
DPH57_RS19585 4574501..4575097 - 597 WP_112939248.1 alpha-ketoglutarate-dependent dioxygenase AlkB -
DPH57_RS19590 4575138..4575716 + 579 WP_112939249.1 molybdopterin-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 150 a.a.        Molecular weight: 16568.83 Da        Isoelectric Point: 5.6434

>T107037 WP_112939244.1 NZ_CP030092:c4570821-4570372 [Massilia sp. YMA4]
MYLLDTNVVSEYRKGARANRGVQAFFAGVQSEELFLPAQVVGEIQAGIARLRRQEDELAAQRARLYESWLEELLETFGAR
VLEFDTEAARVWGTLLGNDKHDPHTIDKQIAAIALVHDLVVVTRDHGTAFKTLRPVRALDPFSLGVPAG

Download         Length: 450 bp

>T107037 NZ_CP030092:c4570821-4570372 [Massilia sp. YMA4]
ATGTATCTGCTCGATACCAACGTCGTTTCGGAGTATCGCAAGGGCGCGCGCGCCAATCGCGGCGTGCAGGCGTTTTTCGC
CGGTGTGCAAAGTGAGGAGTTGTTCCTGCCGGCCCAGGTGGTCGGCGAGATCCAGGCCGGCATTGCCCGGCTGCGCCGGC
AGGAAGACGAACTGGCCGCCCAGCGCGCCCGGCTGTACGAAAGCTGGCTGGAGGAACTGCTCGAGACGTTTGGCGCCCGG
GTGCTGGAATTCGATACCGAGGCGGCGCGCGTGTGGGGCACCTTGCTCGGCAATGACAAACACGATCCGCACACGATCGA
CAAACAGATCGCCGCGATCGCGCTGGTGCACGACCTGGTCGTCGTCACGCGCGACCACGGCACGGCCTTCAAGACCTTGC
GCCCGGTGCGGGCGCTCGACCCGTTCAGCCTCGGCGTACCGGCCGGCTGA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7628.76 Da        Isoelectric Point: 7.0128

>AT107037 WP_112939245.1 NZ_CP030092:c4571033-4570827 [Massilia sp. YMA4]
MAQLLVRDIDEAVVDALKRTAAGNGRSAEAEHREILRGALTVRPKKRSFKEVLAAMPYFEDDALFDVR

Download         Length: 207 bp

>AT107037 NZ_CP030092:c4571033-4570827 [Massilia sp. YMA4]
ATGGCTCAGTTACTGGTACGCGATATCGACGAGGCGGTGGTCGATGCCTTGAAACGCACCGCCGCCGGCAATGGCCGCAG
CGCGGAGGCGGAACACCGCGAAATCCTGCGCGGCGCGTTGACGGTGCGCCCGAAAAAGCGTTCGTTCAAGGAAGTGCTGG
CGGCGATGCCGTATTTCGAGGATGACGCGCTGTTCGACGTGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References