Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 1059493..1060100 Replicon chromosome
Accession NZ_CP030086
Organism Polynucleobacter paneuropaeus strain MWH-Creno-4B4

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag DPM16_RS05335 Protein ID WP_112294466.1
Coordinates 1059493..1059783 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag DPM16_RS05340 Protein ID WP_112204491.1
Coordinates 1059792..1060100 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DPM16_RS05310 1054870..1055487 + 618 WP_112209453.1 response regulator transcription factor -
DPM16_RS05315 1055478..1055795 - 318 WP_158525188.1 helix-turn-helix domain-containing protein -
DPM16_RS05320 1055866..1057014 - 1149 WP_158526016.1 HAMP domain-containing histidine kinase -
DPM16_RS05325 1057429..1058556 + 1128 WP_112318358.1 quinolinate synthase NadA -
DPM16_RS05330 1058563..1059417 + 855 WP_112318359.1 carboxylating nicotinate-nucleotide diphosphorylase -
DPM16_RS05335 1059493..1059783 + 291 WP_112294466.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DPM16_RS05340 1059792..1060100 + 309 WP_112204491.1 putative addiction module antidote protein Antitoxin
DPM16_RS05345 1060191..1061576 - 1386 WP_112318360.1 TRAP transporter substrate-binding protein -
DPM16_RS05350 1061617..1063278 - 1662 WP_112204494.1 L-aspartate oxidase -
DPM16_RS05355 1063319..1063597 - 279 WP_112204496.1 type II toxin-antitoxin system RelE/ParE family toxin -
DPM16_RS05360 1063597..1063824 - 228 WP_112204498.1 ParD-like family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-92)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11102.04 Da        Isoelectric Point: 10.4247

>T107035 WP_112294466.1 NZ_CP030086:1059493-1059783 [Polynucleobacter paneuropaeus]
MLEIRKTEEFKAWLDSLHDLMGRAKIQARIKRLAEGNPGNTKSVGSKVFEMKIDFGPGYRIYYTKHENVMYLLLIGGNKR
TQVKDIQIAKYLAKNI

Download         Length: 291 bp

>T107035 NZ_CP030086:1059493-1059783 [Polynucleobacter paneuropaeus]
ATGCTTGAAATAAGGAAAACAGAAGAATTTAAAGCCTGGCTAGACTCTCTTCATGATTTGATGGGAAGAGCAAAAATTCA
AGCCAGAATTAAACGTTTAGCCGAAGGAAACCCAGGAAATACAAAATCCGTTGGCAGTAAAGTCTTTGAGATGAAGATTG
ATTTTGGGCCTGGCTACAGGATTTATTACACAAAACATGAGAATGTGATGTATCTATTACTTATCGGGGGCAATAAAAGA
ACTCAGGTTAAAGATATTCAGATTGCAAAATATTTAGCCAAAAACATATAG

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 10972.78 Da        Isoelectric Point: 9.8628

>AT107035 WP_112204491.1 NZ_CP030086:1059792-1060100 [Polynucleobacter paneuropaeus]
MKKTIISPYDVVEHLRTPKEMALYLQACIEESNGDAAFIARALGDIARAKGMAQVAKESGLSRESLYKALSGDRIPGFDT
VLKVLAALGLSLHTKPTSKARA

Download         Length: 309 bp

>AT107035 NZ_CP030086:1059792-1060100 [Polynucleobacter paneuropaeus]
ATGAAAAAGACAATTATCAGTCCTTATGATGTAGTGGAGCACTTACGTACCCCAAAGGAAATGGCGCTTTATCTACAAGC
ATGTATTGAAGAATCCAATGGGGATGCGGCGTTTATAGCAAGAGCGCTTGGTGATATAGCGCGCGCAAAAGGAATGGCTC
AGGTAGCTAAGGAATCCGGGCTCTCAAGGGAAAGCCTTTACAAAGCCTTGTCTGGCGATCGAATACCGGGGTTTGATACT
GTATTAAAGGTGCTGGCAGCTCTTGGTCTGAGTCTGCATACAAAACCCACTAGTAAAGCTCGCGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References