Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 128054..128592 Replicon chromosome
Accession NZ_CP030086
Organism Polynucleobacter paneuropaeus strain MWH-Creno-4B4

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag DPM16_RS00755 Protein ID WP_112294202.1
Coordinates 128054..128380 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag DPM16_RS00760 Protein ID WP_112294203.1
Coordinates 128377..128592 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DPM16_RS00730 124104..124412 - 309 WP_112317990.1 Grx4 family monothiol glutaredoxin -
DPM16_RS00735 124495..125337 - 843 WP_112317991.1 peptide chain release factor N(5)-glutamine methyltransferase -
DPM16_RS00740 125344..126423 - 1080 WP_112317992.1 peptide chain release factor 1 -
DPM16_RS00745 126424..127740 - 1317 WP_112317993.1 glutamyl-tRNA reductase -
DPM16_RS00755 128054..128380 - 327 WP_112294202.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DPM16_RS00760 128377..128592 - 216 WP_112294203.1 antitoxin MazE family protein Antitoxin
DPM16_RS00765 128707..129429 - 723 WP_112294204.1 uracil-DNA glycosylase -
DPM16_RS00770 129440..131221 - 1782 WP_112318550.1 M61 family metallopeptidase -
DPM16_RS00775 131238..131972 - 735 WP_112317994.1 DsbC family protein -
DPM16_RS00780 131950..133224 - 1275 WP_112317995.1 FAD-dependent monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-103)

Antitoxin

Antitoxin MazE-like

(8-70)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11741.74 Da        Isoelectric Point: 8.7358

>T107031 WP_112294202.1 NZ_CP030086:c128380-128054 [Polynucleobacter paneuropaeus]
MKRGSLVTIAMQGDFGKPRPALVIQSDVFNEVHSTVTVLLVSGEKVDAPLFRLDVLPSPENGLTKLSQIQVDKIMSVRSE
KIGSKIGQLDDAEMLRVNRALGLWLGLG

Download         Length: 327 bp

>T107031 NZ_CP030086:c128380-128054 [Polynucleobacter paneuropaeus]
ATGAAGCGAGGCAGTCTTGTAACCATTGCAATGCAGGGTGATTTTGGTAAACCCCGGCCAGCGCTTGTAATCCAATCTGA
TGTGTTTAACGAGGTCCACTCTACCGTAACAGTTCTACTCGTATCCGGTGAGAAAGTTGACGCTCCGCTATTTAGGCTTG
ATGTCCTTCCCAGCCCAGAAAATGGACTTACCAAACTCTCTCAGATCCAAGTGGACAAAATTATGTCCGTGCGAAGTGAA
AAGATAGGGTCAAAAATTGGGCAACTTGATGACGCTGAAATGCTCAGGGTCAATCGTGCTTTGGGTTTATGGCTTGGTCT
GGGCTAG

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7842.93 Da        Isoelectric Point: 8.0287

>AT107031 WP_112294203.1 NZ_CP030086:c128592-128377 [Polynucleobacter paneuropaeus]
MGSSTAIRVQKHRVSLRNAGLRPIQLWVPDTRVPGFKKECARQSSLAAMTDRADQDLMSFLDDALNDLGGE

Download         Length: 216 bp

>AT107031 NZ_CP030086:c128592-128377 [Polynucleobacter paneuropaeus]
ATGGGCTCCAGCACCGCAATTCGAGTACAAAAACATCGGGTTTCGCTTCGAAATGCGGGTCTAAGGCCGATCCAACTCTG
GGTTCCGGATACTCGGGTTCCGGGATTTAAGAAAGAATGTGCTCGTCAATCTTCCTTGGCGGCAATGACTGATCGGGCGG
ATCAGGATTTAATGTCCTTCCTTGATGATGCCCTGAATGATTTAGGCGGCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References