Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4174373..4175112 Replicon chromosome
Accession NZ_CP030076
Organism Enterobacter hormaechei strain 20710

Toxin (Protein)


Gene name tacT Uniprot ID A0A837FFP9
Locus tag DPF84_RS20625 Protein ID WP_032609220.1
Coordinates 4174373..4174858 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag DPF84_RS20630 Protein ID WP_003857131.1
Coordinates 4174846..4175112 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DPF84_RS20595 4169864..4170436 + 573 WP_045346197.1 NAD(P)H-dependent oxidoreductase -
DPF84_RS20600 4170439..4171458 + 1020 WP_045346198.1 aldo/keto reductase -
DPF84_RS20605 4171497..4171874 + 378 WP_023292403.1 DUF1330 domain-containing protein -
DPF84_RS20610 4171911..4172516 + 606 WP_071957458.1 NAD(P)H-dependent oxidoreductase -
DPF84_RS20615 4172557..4173252 + 696 WP_045346199.1 antibiotic biosynthesis monooxygenase -
DPF84_RS20620 4173268..4174071 + 804 WP_112777707.1 carboxymuconolactone decarboxylase family protein -
DPF84_RS20625 4174373..4174858 - 486 WP_032609220.1 GNAT family N-acetyltransferase Toxin
DPF84_RS20630 4174846..4175112 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
DPF84_RS20635 4175176..4176105 - 930 WP_045346202.1 LysR family transcriptional regulator -
DPF84_RS20640 4176235..4177623 + 1389 WP_023314162.1 MFS transporter -
DPF84_RS20645 4177645..4178640 - 996 WP_045346203.1 DUF2891 domain-containing protein -
DPF84_RS20650 4178650..4179636 - 987 WP_003857123.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(80-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17554.26 Da        Isoelectric Point: 9.9658

>T107024 WP_032609220.1 NZ_CP030076:c4174858-4174373 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVICKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T107024 NZ_CP030076:c4174858-4174373 [Enterobacter hormaechei]
GTGGGACGTGTAACAGCGCCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGCGGAGAGGCCGTGCTTGA
CGAATGGCTAAAACAAAGAGGTCTGAAAAACCAGGCGCTCGGCGCAGCCCGAACGTTTGTCATTTGTAAAACGGGCACGA
AGCAGGTCGCGGGATTTTACTCACTGGCTACCGGCAGCGTTAACCATACGCAAGCGACAGGTAATCTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATACTTGCCCGTCTGGCTGTTGATGTCTCGTTACGCGGAAACGGGTTGGGAGCCGATTT
ACTCCACGATGCGGTTTTACGCTGTTATCGGGTAGCTGAGAATATTGGGGTGCGGGCGATCATGGTTCATGCACTCACTG
AGGAAGCCAAAGCGTTTTATATCCACCATGGTTTTAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCCGGCTTCCT
CAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT107024 WP_003857131.1 NZ_CP030076:c4175112-4174846 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT107024 NZ_CP030076:c4175112-4174846 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTCAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGTACAGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAGAATGTGATCCTCGATCGACGTGTATTCAATT
TTAACGATGAACAGTACGCAGAGTTCATTGACATGCTCGATGCCCCGGTCGCGGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCGCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References