Detailed information of TA system TA107011

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 1805880..1806598
• Replicon: chromosome
• Accession: NZ_CP030076
• Organism: Enterobacter hormaechei strain 20710

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A822WUK4
• Locus tag: DPF84_RS09080
• Protein ID: WP_071605960.1
• Coordinates: 1806278..1806598 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: DPF84_RS09075
• Protein ID: WP_044599779.1
• Coordinates: 1805880..1806236 (+)
• Length: 119 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DPF84_RS09045	1802231..1802665	+	435	WP_044599777.1	hypothetical protein	-
DPF84_RS09050	1802725..1803564	+	840	WP_052735741.1	hypothetical protein	-
DPF84_RS09060	1804257..1805078	+	822	WP_044599778.1	DUF945 domain-containing protein	-
DPF84_RS09065	1805148..1805618	+	471	WP_023305179.1	DNA repair protein RadC	-
DPF84_RS09070	1805627..1805848	+	222	WP_057696015.1	DUF987 family protein	-
DPF84_RS09075	1805880..1806236	+	357	WP_044599779.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
DPF84_RS09080	1806278..1806598	+	321	WP_071605960.1	TA system toxin CbtA family protein	Toxin
DPF84_RS09085	1806779..1808536	+	1758	WP_126814668.1	hypothetical protein	-
DPF84_RS09090	1808538..1808729	-	192	WP_072034772.1	toxin-antitoxin system HicB family antitoxin	-
DPF84_RS09095	1808866..1809207	+	342	WP_006812446.1	SymE family type I addiction module toxin	-
DPF84_RS09100	1809266..1810294	+	1029	WP_072021525.1	virulence RhuM family protein	-
DPF84_RS09105	1810558..1811044	+	487	Protein_1719	type VI secretion system tube protein Hcp	-
DPF84_RS09110	1811054..1811419	+	366	WP_072034771.1	DUF2778 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1785820..1827253	41433

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (5-104)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12227.83 Da
• Isoelectric Point: 6.3229

>T107011 WP_071605960.1 NZ_CP030076:1806278-1806598 [Enterobacter hormaechei]
MHISTVPKTVTVSSRLSPVQVWQKLLTYILEHHYGLTINDTPFSNDTTIQEHIEAGVNLTDAVNFLVERFELVRIDQKSF
SWQDQEPWITSLDVHRAQSNLGLKRP

Nucleotide

• Length: 321 bp

>T107011 NZ_CP030076:1806278-1806598 [Enterobacter hormaechei]
ATGCATATTTCGACTGTACCGAAAACAGTGACGGTTTCGTCACGCCTGTCTCCTGTCCAAGTTTGGCAAAAACTATTAAC
GTATATTTTAGAGCATCATTACGGCCTCACGATCAACGACACACCGTTCAGTAACGATACGACGATTCAGGAACATATAG
AGGCGGGAGTGAATCTTACTGATGCTGTTAATTTCCTTGTGGAACGATTCGAGCTTGTGCGCATTGACCAGAAGAGTTTC
TCCTGGCAGGATCAAGAACCCTGGATAACATCTTTGGATGTTCATCGGGCACAGTCCAACCTTGGCTTGAAACGCCCATA
A

Antitoxin

Protein

• Length: 119 a.a.
• Molecular weight: 13081.91 Da
• Isoelectric Point: 7.7487

>AT107011 WP_044599779.1 NZ_CP030076:1805880-1806236 [Enterobacter hormaechei]
MQSTTISGTSAKNTSCLQWGLKRNITPCFGARLVQKGKRLYFLADRAGFNGSFSDAEALSLDQAFPLMVKQLERMLTTGE
LDPHNQHCVTLHHNGLTCEADTLGSYGYVYIAIYPHQL

Nucleotide

• Length: 357 bp

>AT107011 NZ_CP030076:1805880-1806236 [Enterobacter hormaechei]
ATGCAGTCGACCACCATATCCGGCACATCGGCGAAGAACACATCCTGCCTTCAGTGGGGATTAAAACGTAATATCACGCC
GTGCTTCGGCGCTCGTCTGGTACAGAAAGGCAAGCGCCTATACTTTTTGGCTGACCGGGCAGGATTTAATGGCTCATTCA
GTGACGCAGAAGCATTGAGTCTGGACCAAGCGTTTCCACTAATGGTGAAACAGCTTGAGCGGATGCTGACAACTGGCGAG
CTTGATCCTCACAACCAGCACTGCGTCACACTGCATCACAATGGACTTACTTGTGAAGCTGACACTCTCGGCTCTTATGG
CTACGTTTATATCGCCATTTATCCCCATCAGCTATAA

Structures

Toxin

• AlphaFold DB: A0A822WUK4