Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4333238..4333895 Replicon chromosome
Accession NZ_CP030070
Organism Klebsiella pneumoniae strain IA565

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag DPF99_RS23285 Protein ID WP_002916310.1
Coordinates 4333238..4333648 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag DPF99_RS23290 Protein ID WP_002916312.1
Coordinates 4333629..4333895 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DPF99_RS23265 4329238..4330971 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
DPF99_RS23270 4330977..4331690 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
DPF99_RS23275 4331713..4332609 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
DPF99_RS23280 4332710..4333231 + 522 WP_002916308.1 flavodoxin FldB -
DPF99_RS23285 4333238..4333648 - 411 WP_002916310.1 protein YgfX Toxin
DPF99_RS23290 4333629..4333895 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
DPF99_RS23295 4334141..4335124 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
DPF99_RS23300 4335223..4335882 - 660 WP_002916317.1 hemolysin III family protein -
DPF99_RS23305 4336046..4336357 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
DPF99_RS23310 4336407..4337135 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
DPF99_RS23315 4337254..4338687 + 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T106987 WP_002916310.1 NZ_CP030070:c4333648-4333238 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T106987 NZ_CP030070:c4333648-4333238 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT106987 WP_002916312.1 NZ_CP030070:c4333895-4333629 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT106987 NZ_CP030070:c4333895-4333629 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References