Detailed information of TA system TA106951

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB-HicA
• Location: 201907..202499
• Replicon: plasmid unnamed
• Accession: NZ_CP030049
• Organism: Bradyrhizobium sp. CCBAU 53338

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: XH90_RS35215
• Protein ID: WP_128929956.1
• Coordinates: 201907..202095 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: XH90_RS35220
• Protein ID: WP_128929955.1
• Coordinates: 202101..202499 (+)
• Length: 133 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XH90_RS35185	197825..198154	-	330	WP_128930197.1	EAL domain-containing protein	-
XH90_RS35190	198223..198597	+	375	WP_188637391.1	hypothetical protein	-
XH90_RS35195	198774..199247	+	474	WP_128929538.1	transposase	-
XH90_RS35200	199244..199598	+	355	Protein_186	IS66 family insertion sequence element accessory protein TnpB	-
XH90_RS35205	199649..201208	+	1560	WP_128929539.1	IS66 family transposase	-
XH90_RS35210	201241..201831	+	591	WP_128930143.1	UPF0149 family protein	-
XH90_RS35215	201907..202095	+	189	WP_128929956.1	type II toxin-antitoxin system HicA family toxin	Toxin
XH90_RS35220	202101..202499	+	399	WP_128929955.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
XH90_RS35225	203153..204349	-	1197	Protein_191	Fic family protein	-
XH90_RS35230	204827..205405	+	579	WP_128929954.1	helix-turn-helix domain-containing protein	-
XH90_RS35235	205398..206621	+	1224	WP_128929953.1	type II toxin-antitoxin system HipA family toxin	-
XH90_RS35240	206900..207220	-	321	WP_128929952.1	ferredoxin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	gmd	1..979291	979291

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-124)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7077.32 Da
• Isoelectric Point: 11.2092

>T106951 WP_128929956.1 NZ_CP030049:201907-202095 [Bradyrhizobium sp. CCBAU 53338]
MKSREIISILQGDGWFEVGRKGSHVQFKHPFKKGRVIVPHPERDVPLGTLKSIEKQSGLKLR

Nucleotide

• Length: 189 bp

>T106951 NZ_CP030049:201907-202095 [Bradyrhizobium sp. CCBAU 53338]
ATGAAAAGCCGGGAAATTATCTCGATCCTTCAAGGGGATGGATGGTTTGAGGTGGGCCGGAAAGGCAGCCATGTGCAGTT
CAAACATCCATTCAAGAAGGGTCGCGTAATTGTTCCGCACCCCGAACGGGATGTCCCACTCGGGACACTGAAGAGTATTG
AAAAGCAGTCAGGTCTCAAACTGAGGTAA

Antitoxin

Protein

• Length: 133 a.a.
• Molecular weight: 14163.96 Da
• Isoelectric Point: 4.3695

>AT106951 WP_128929955.1 NZ_CP030049:202101-202499 [Bradyrhizobium sp. CCBAU 53338]
MRNYIGLIHKDADSDFGVSFPDFPGVITAGKSLDDARAMAEEALTLHIEGLAEDGEAIPEPSTLEDVMADPDHRTGVAIL
VSVKPEQPKAIRVNVTLPEDVLNQIDKYAEAHGFTRSGLLTQAAKRLIGEAA

Nucleotide

• Length: 399 bp

>AT106951 NZ_CP030049:202101-202499 [Bradyrhizobium sp. CCBAU 53338]
ATGCGTAACTATATTGGTCTTATCCATAAGGATGCCGACAGCGATTTCGGCGTCTCATTTCCAGACTTCCCCGGAGTGAT
CACGGCAGGCAAAAGCCTTGATGACGCTCGTGCTATGGCAGAGGAAGCCCTCACCCTTCATATCGAGGGTCTTGCTGAAG
ATGGAGAAGCCATTCCGGAGCCCTCTACTCTAGAGGATGTTATGGCAGATCCTGATCATCGAACTGGGGTAGCTATTTTG
GTGTCGGTCAAACCCGAACAACCAAAGGCTATACGTGTGAATGTCACCCTTCCTGAGGACGTTCTGAATCAGATCGACAA
ATATGCTGAAGCGCACGGCTTTACGAGATCGGGCCTCCTAACTCAGGCCGCGAAGAGACTCATAGGAGAAGCAGCCTAA