106913

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_19(antitoxin)
Location 1070436..1071121 Replicon chromosome
Accession NZ_CP030042
Organism Enterococcus faecalis strain C25

Toxin (Protein)


Gene name IrrE Uniprot ID -
Locus tag DOU31_RS05335 Protein ID WP_002395798.1
Coordinates 1070436..1070780 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag DOU31_RS05340 Protein ID WP_010826721.1
Coordinates 1070798..1071121 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DOU31_RS05305 1065715..1066683 + 969 WP_002398077.1 Flp pilus assembly complex ATPase component TadA -
DOU31_RS05310 1066640..1067686 + 1047 WP_002369171.1 type II secretion system F family protein -
DOU31_RS05315 1067686..1067961 + 276 WP_002356991.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -
DOU31_RS05320 1067958..1068395 + 438 WP_138807094.1 hypothetical protein -
DOU31_RS05325 1068429..1069577 - 1149 WP_138807096.1 site-specific integrase -
DOU31_RS05330 1069674..1070402 - 729 WP_138807098.1 potassium channel family protein -
DOU31_RS05335 1070436..1070780 - 345 WP_002395798.1 ImmA/IrrE family metallo-endopeptidase Toxin
DOU31_RS05340 1070798..1071121 - 324 WP_010826721.1 helix-turn-helix domain-containing protein Antitoxin
DOU31_RS05345 1071432..1071608 + 177 WP_002364354.1 helix-turn-helix transcriptional regulator -
DOU31_RS05350 1071619..1071930 + 312 WP_002381719.1 hypothetical protein -
DOU31_RS05355 1071937..1072116 + 180 WP_002395800.1 hypothetical protein -
DOU31_RS15185 1072339..1072533 + 195 WP_181444835.1 hypothetical protein -
DOU31_RS05365 1072748..1072948 + 201 WP_105194762.1 hypothetical protein -
DOU31_RS05370 1072945..1073238 + 294 WP_010826715.1 VRR-NUC domain-containing protein -
DOU31_RS05375 1073228..1074424 + 1197 WP_016626781.1 DEAD/DEAH box helicase -
DOU31_RS05380 1074426..1074668 + 243 WP_010826713.1 hypothetical protein -
DOU31_RS05385 1074681..1075592 + 912 WP_138807100.1 YqaJ viral recombinase family protein -
DOU31_RS05390 1075594..1075812 + 219 WP_002407623.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(22-81)

Antitoxin

Cro/C1-type helix-turn-helix domain

(5-59)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13718.69 Da        Isoelectric Point: 6.1363

>T106913 WP_002395798.1 NZ_CP030042:c1070780-1070436 [Enterococcus faecalis]
MKSIKELVEEYEVELVFAPINKRACYEPVKRIIFVNQNLSIEEQEESIFHEFKHVVSHSDYMELYKIPSFRNKMEAEADH
HMFKCLIEKHDGQFNYSNVITHYNLKMGQETYLK

Download         Length: 345 bp

>T106913 NZ_CP030042:c1070780-1070436 [Enterococcus faecalis]
ATGAAAAGTATCAAAGAGTTGGTGGAAGAATATGAAGTAGAGTTAGTTTTCGCTCCAATAAATAAGCGCGCATGTTACGA
GCCAGTCAAAAGAATAATTTTCGTAAATCAAAATTTATCTATCGAAGAACAAGAAGAGTCTATATTCCATGAGTTCAAAC
ATGTTGTTTCCCATTCGGATTACATGGAGTTATATAAAATCCCTTCTTTTAGAAATAAGATGGAAGCTGAGGCGGATCAT
CATATGTTTAAATGCCTTATTGAAAAACATGACGGGCAATTTAATTATTCTAATGTGATTACTCATTACAATTTAAAGAT
GGGACAAGAAACTTATTTAAAATAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12330.96 Da        Isoelectric Point: 5.2520

>AT106913 WP_010826721.1 NZ_CP030042:c1071121-1070798 [Enterococcus faecalis]
MTVFDRVKKLADSQKISIVELEEKLNFSRNSLYAWKKSKPSIDKLEAVANYFGVSTDYLLGREISNKPKQSDDLDEILDN
VMSFDGEPLDDHDREVIRAYLKGRFGK

Download         Length: 324 bp

>AT106913 NZ_CP030042:c1071121-1070798 [Enterococcus faecalis]
ATGACTGTATTTGATAGAGTTAAAAAATTAGCAGATAGTCAGAAAATATCTATTGTGGAACTTGAAGAAAAGTTAAATTT
TAGTCGAAATTCATTGTATGCTTGGAAAAAAAGCAAGCCTTCTATCGATAAATTAGAAGCTGTCGCAAATTATTTTGGAG
TTTCAACGGATTATTTATTGGGTCGTGAAATCTCTAATAAACCAAAGCAATCTGATGATTTGGATGAAATTTTAGACAAT
GTGATGAGTTTTGATGGTGAGCCTTTGGATGATCATGATCGGGAAGTTATTCGTGCTTATTTGAAAGGGAGATTCGGAAA
ATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References