Detailed information of TA system TA106894

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 501048..501589
• Replicon: chromosome
• Accession: NZ_CP030041
• Organism: Echinicola strongylocentroti strain MEBiC08714

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: DN752_RS01920
• Protein ID: WP_112782410.1
• Coordinates: 501287..501589 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: DN752_RS01915
• Protein ID: WP_112782409.1
• Coordinates: 501048..501290 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DN752_RS01885	496365..497300	+	936	WP_112782403.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
DN752_RS01890	497358..497741	+	384	WP_112782404.1	STAS domain-containing protein	-
DN752_RS01895	497744..498655	+	912	WP_112782405.1	ribonuclease Z	-
DN752_RS01900	498659..499459	+	801	WP_112782406.1	queuosine precursor transporter	-
DN752_RS01905	499652..500056	+	405	WP_112782407.1	hypothetical protein	-
DN752_RS01910	500098..500934	+	837	WP_162633077.1	hypothetical protein	-
DN752_RS01915	501048..501290	+	243	WP_112782409.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
DN752_RS01920	501287..501589	+	303	WP_112782410.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DN752_RS01925	502108..502911	+	804	WP_112782411.1	AraC family transcriptional regulator	-
DN752_RS01930	502995..503540	+	546	WP_112782412.1	cupin domain-containing protein	-
DN752_RS01935	503605..504615	-	1011	WP_112782413.1	bile acid:sodium symporter	-
DN752_RS01940	504747..505493	-	747	WP_112782414.1	RNA methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-94)

Antitoxin

• Antitoxin ParD (1-79)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 12220.00 Da
• Isoelectric Point: 9.8501

>T106894 WP_112782410.1 NZ_CP030041:501287-501589 [Echinicola strongylocentroti]
MSKNKYRISKQAIEDLNYIWVYTFHNWSKEQADRYYDLIIGEIEFIADNYLSGKSADQTRKNYRVTNIKSHLIFYRKVEN
EIVEITRILHQRMDIKKQLK

Nucleotide

• Length: 303 bp

>T106894 NZ_CP030041:501287-501589 [Echinicola strongylocentroti]
ATGAGTAAAAACAAGTATCGAATAAGTAAACAAGCGATTGAAGATTTAAATTATATTTGGGTTTATACTTTTCACAATTG
GTCTAAAGAACAGGCAGATAGGTACTACGACTTAATAATCGGAGAGATTGAATTTATAGCGGACAACTATTTGAGTGGAA
AATCCGCGGATCAAACTCGAAAAAATTATCGAGTGACAAATATCAAGTCACATTTGATTTTTTACAGAAAAGTGGAAAAT
GAGATTGTTGAAATCACTAGAATTTTACATCAAAGAATGGACATTAAAAAACAACTGAAATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9269.38 Da
• Isoelectric Point: 5.6744

>AT106894 WP_112782409.1 NZ_CP030041:501048-501290 [Echinicola strongylocentroti]
MGKNTSISLGNHFEEFIREEVNSGRYGSVSEVIRSALRLLEREEKKERELIKALEVGENSGFVEDFDPKQNLAELHRRHL

Nucleotide

• Length: 243 bp

>AT106894 NZ_CP030041:501048-501290 [Echinicola strongylocentroti]
ATGGGAAAAAACACATCAATATCACTCGGAAATCATTTTGAGGAGTTTATCAGAGAAGAAGTAAATTCTGGTAGGTATGG
TTCAGTTAGCGAAGTTATTCGTTCCGCATTACGTTTGTTAGAACGTGAAGAAAAAAAGGAAAGAGAATTGATTAAAGCTC
TCGAAGTTGGAGAAAATAGCGGGTTTGTTGAAGATTTCGATCCAAAACAGAATCTGGCTGAATTACATCGTCGACACTTA
TGA