Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 19528..20053 Replicon plasmid pSA20120345.1
Accession NZ_CP030025
Organism Salmonella enterica subsp. enterica serovar Ohio strain SA20120345

Toxin (Protein)


Gene name ccdB Uniprot ID F0JY91
Locus tag DOE64_RS24375 Protein ID WP_001159869.1
Coordinates 19748..20053 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID H9TJP1
Locus tag DOE64_RS24370 Protein ID WP_000813630.1
Coordinates 19528..19746 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DOE64_RS24335 14529..15119 - 591 WP_000194550.1 hypothetical protein -
DOE64_RS24340 15119..15373 - 255 WP_000343103.1 hypothetical protein -
DOE64_RS24345 15725..16726 + 1002 WP_000774875.1 DUF4238 domain-containing protein -
DOE64_RS24350 16902..17246 - 345 WP_000793307.1 hypothetical protein -
DOE64_RS24355 17745..17999 - 255 WP_000678527.1 hypothetical protein -
DOE64_RS24360 18044..18970 - 927 WP_001290416.1 hypothetical protein -
DOE64_RS24370 19528..19746 + 219 WP_000813630.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
DOE64_RS24375 19748..20053 + 306 WP_001159869.1 type II toxin-antitoxin system toxin CcdB Toxin
DOE64_RS24380 20054..20860 + 807 WP_000016969.1 site-specific integrase -
DOE64_RS24385 21040..21684 + 645 WP_001144036.1 ParA family protein -
DOE64_RS24390 21771..22079 + 309 WP_000030199.1 hypothetical protein -
DOE64_RS24395 22493..23473 + 981 WP_000688514.1 plasmid segregation protein ParM -
DOE64_RS24400 23466..23882 + 417 WP_001278818.1 plasmid partitioning/stability family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..100335 100335


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-53)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 13091.77 Da        Isoelectric Point: 12.8043

>T106885 WP_001159869.1 NZ_CP030025:19748-20053 [Salmonella enterica subsp. enterica serovar Ohio]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Download         Length: 306 bp

>T106885 NZ_CP030025:19748-20053 [Salmonella enterica subsp. enterica serovar Ohio]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 9374.72 Da        Isoelectric Point: 12.6573

>AT106885 WP_000813630.1 NZ_CP030025:19528-19746 [Salmonella enterica subsp. enterica serovar Ohio]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 219 bp

>AT106885 NZ_CP030025:19528-19746 [Salmonella enterica subsp. enterica serovar Ohio]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2SIB9

Antitoxin

Source ID Structure
AlphaFold DB A0A829CEF5

References