Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 1986..2533 Replicon plasmid pSA20120345.1
Accession NZ_CP030025
Organism Salmonella enterica subsp. enterica serovar Ohio strain SA20120345

Toxin (Protein)


Gene name parE Uniprot ID W0LWB3
Locus tag DOE64_RS24250 Protein ID WP_000970007.1
Coordinates 2252..2533 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag DOE64_RS24245 Protein ID WP_000079941.1
Coordinates 1986..2255 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DOE64_RS24230 46..1077 + 1032 WP_000907873.1 replication initiation protein -
DOE64_RS24245 1986..2255 + 270 WP_000079941.1 hypothetical protein Antitoxin
DOE64_RS24250 2252..2533 + 282 WP_000970007.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DOE64_RS24255 2573..3421 + 849 WP_001057992.1 3'-5' exonuclease -
DOE64_RS24260 3538..4011 + 474 WP_001334658.1 hypothetical protein -
DOE64_RS24270 4488..4754 - 267 WP_000955263.1 hypothetical protein -
DOE64_RS24275 4754..5248 - 495 WP_001459505.1 hypothetical protein -
DOE64_RS24280 5304..5906 - 603 WP_000517695.1 hypothetical protein -
DOE64_RS24290 6260..7144 + 885 Protein_8 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..100335 100335


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Ribbon-helix-helix protein, CopG

(4-39)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 12066.38 Da        Isoelectric Point: 12.7685

>T106884 WP_000970007.1 NZ_CP030025:2252-2533 [Salmonella enterica subsp. enterica serovar Ohio]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKK

Download         Length: 282 bp

>T106884 NZ_CP030025:2252-2533 [Salmonella enterica subsp. enterica serovar Ohio]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 11553.68 Da        Isoelectric Point: 12.7493

>AT106884 WP_000079941.1 NZ_CP030025:1986-2255 [Salmonella enterica subsp. enterica serovar Ohio]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKK

Download         Length: 270 bp

>AT106884 NZ_CP030025:1986-2255 [Salmonella enterica subsp. enterica serovar Ohio]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7G1GDN5

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References