Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1309880..1310366 Replicon chromosome
Accession NZ_CP030023
Organism Streptococcus suis strain ISU2414

Toxin (Protein)


Gene name relE Uniprot ID A0A0K2E5U8
Locus tag DK877_RS06565 Protein ID WP_002935012.1
Coordinates 1310109..1310366 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0K2E5B0
Locus tag DK877_RS06560 Protein ID WP_002935014.1
Coordinates 1309880..1310119 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DK877_RS06530 1305529..1305666 + 138 WP_002935027.1 hypothetical protein -
DK877_RS06535 1305679..1306413 + 735 WP_002935025.1 beta-carotene 15,15'-monooxygenase -
DK877_RS06540 1306512..1306652 + 141 WP_002935023.1 hypothetical protein -
DK877_RS06545 1306665..1307048 + 384 WP_002935021.1 NisI/SpaI family lantibiotic immunity lipoprotein -
DK877_RS06550 1307065..1307817 + 753 WP_002935019.1 ABC transporter ATP-binding protein -
DK877_RS06555 1307818..1309788 + 1971 WP_013730363.1 FtsX-like permease family protein -
DK877_RS06560 1309880..1310119 + 240 WP_002935014.1 hypothetical protein Antitoxin
DK877_RS06565 1310109..1310366 + 258 WP_002935012.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DK877_RS06570 1310405..1311070 + 666 WP_009909826.1 response regulator transcription factor -
DK877_RS06575 1311067..1312008 + 942 WP_002935009.1 sensor histidine kinase -
DK877_RS06580 1312084..1313592 + 1509 WP_013730362.1 phosphoglucomutase -
DK877_RS06585 1313662..1314732 - 1071 WP_002935006.1 tyrosine recombinase XerS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1245742..1314732 68990


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-75)

Antitoxin

Protein of unknown function DUF6290

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9849.52 Da        Isoelectric Point: 10.7134

>T106882 WP_002935012.1 NZ_CP030023:1310109-1310366 [Streptococcus suis]
MSYKVILSAKAQKQIRKMDKTAASLILRYLYKHIDGCDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI

Download         Length: 258 bp

>T106882 NZ_CP030023:1310109-1310366 [Streptococcus suis]
TTGAGTTATAAGGTTATTTTGTCTGCTAAGGCCCAAAAGCAAATTCGAAAGATGGATAAAACCGCTGCAAGTTTGATTTT
GCGCTATCTCTACAAGCATATTGACGGTTGCGACAACCCTAGACAATACGGAAAAGCCTTGACTGCTAATCGTTCTGGCC
AATGGCGCTATCGTATCGGCAATTACAGGGTTATCGTTAATATTGAAGATGATAAATTGATTGTGACAAGCATAAAAATG
AGAAATGGAAGTATATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8924.19 Da        Isoelectric Point: 3.9191

>AT106882 WP_002935014.1 NZ_CP030023:1309880-1310119 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADVAWAEYQADLANRIEPMTLEQMAEELGIEL

Download         Length: 240 bp

>AT106882 NZ_CP030023:1309880-1310119 [Streptococcus suis]
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCCCTTGAAGACGAGTACGATGCGCGTGTGGCAGACGTTGCTTGGGCAG
AATACCAAGCAGACTTGGCGAATAGAATTGAGCCGATGACATTAGAACAAATGGCTGAGGAGTTGGGCATTGAGTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K2E5U8

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E5B0

References