Detailed information of TA system TA106881

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sezT-pezT/zeta-couple_hipB
• Location: 1224724..1225994
• Replicon: chromosome
• Accession: NZ_CP030023
• Organism: Streptococcus suis strain ISU2414

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: A0A0Z8INM2
• Locus tag: DK877_RS06170
• Protein ID: WP_024409332.1
• Coordinates: 1225200..1225994 (+)
• Length: 265 a.a.

Antitoxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: DK877_RS06165
• Protein ID: WP_024409333.1
• Coordinates: 1224724..1225200 (+)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DK877_RS06125	1220184..1221095	+	912	WP_032505215.1	hypothetical protein	-
DK877_RS06130	1221165..1221464	+	300	WP_024382151.1	hypothetical protein	-
DK877_RS06135	1221479..1221769	+	291	WP_024409338.1	hypothetical protein	-
DK877_RS06140	1221880..1222518	+	639	WP_024409337.1	hypothetical protein	-
DK877_RS06145	1222558..1223646	+	1089	WP_024409336.1	toprim domain-containing protein	-
DK877_RS06150	1223700..1223927	+	228	WP_024409335.1	hypothetical protein	-
DK877_RS06155	1223931..1224326	+	396	WP_017285409.1	hypothetical protein	-
DK877_RS06160	1224370..1224654	+	285	WP_024409334.1	hypothetical protein	-
DK877_RS06165	1224724..1225200	+	477	WP_024409333.1	helix-turn-helix domain-containing protein	Antitoxin
DK877_RS06170	1225200..1225994	+	795	WP_024409332.1	zeta toxin family protein	Toxin
DK877_RS06175	1225975..1226178	+	204	Protein_1174	AAA family ATPase	-
DK877_RS06180	1226269..1227213	+	945	WP_024409330.1	IS30 family transposase	-
DK877_RS06185	1227221..1229044	+	1824	Protein_1176	AAA family ATPase	-
DK877_RS06190	1229041..1230954	+	1914	WP_053338584.1	ATP-dependent helicase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	tet(O)	-	1209912..1245739	35827

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (26-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 265 a.a.
• Molecular weight: 30360.57 Da
• Isoelectric Point: 6.6151

>T106881 WP_024409332.1 NZ_CP030023:1225200-1225994 [Streptococcus suis]
MRLEEFSKDDFDLALKRTIRSLTRGKTTSVTPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSLHPNYLTLQE
EYGKDSVDYTKGFAGKMVEQLVDELSKQGYHLLIEGTLRTTEVPRKTARLLKARGYQVSLALIATKPELSYLSTLIRYEE
VYVVNPNQARATPKEHHDGIVNHLVDNLRELENDHLFDYIQIYQRDRSCVYDSETDDGSAAEVLQECLFGKWSKVEEEMM
KMGQELLMEFLEMKKGRIYENKKN

Nucleotide

• Length: 795 bp

>T106881 NZ_CP030023:1225200-1225994 [Streptococcus suis]
ATGCGGTTAGAAGAATTTAGCAAAGATGACTTTGACTTAGCCTTAAAACGAACTATTCGTTCCTTAACTCGTGGTAAAAC
GACATCAGTTACCCCAAAAGCCATCTTACTTGGTGGGCAAAGTGGAGCAGGAAAAACAACGATACACCGTATCAAGCAGA
AAGAGTTCCAAGGTAATATTATCATTATTGACGGTGATAGCTACCGCTCTTTACACCCGAATTATCTAACTTTACAAGAA
GAGTACGGGAAGGATAGCGTGGATTATACCAAAGGTTTTGCAGGAAAAATGGTGGAACAGCTTGTGGATGAACTCAGTAA
ACAAGGTTATCATTTGTTAATCGAAGGAACTTTGAGAACGACAGAAGTCCCACGAAAAACAGCACGGCTATTGAAAGCGA
GAGGTTATCAAGTCTCATTAGCTTTGATAGCAACCAAGCCTGAATTGTCTTATCTCAGCACCTTAATCCGCTACGAAGAA
GTCTATGTGGTTAATCCAAACCAAGCTAGAGCAACTCCTAAAGAACATCATGATGGAATTGTCAATCACTTGGTTGATAA
CTTACGAGAGCTAGAAAACGACCATCTCTTTGATTATATTCAAATTTATCAAAGAGATAGAAGTTGTGTTTATGATTCGG
AAACTGATGACGGTTCAGCAGCAGAAGTGCTACAAGAATGCCTCTTCGGAAAATGGAGCAAGGTGGAGGAAGAGATGATG
AAGATGGGACAGGAATTGTTGATGGAGTTTTTGGAAATGAAAAAAGGTAGAATTTATGAAAATAAAAAAAATTAA

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18119.46 Da
• Isoelectric Point: 4.3193

>AT106881 WP_024409333.1 NZ_CP030023:1224724-1225200 [Streptococcus suis]
MIGDNIKSLRKTHDLTQPEFAKIVGISRNSLSRYENGTSSLSTELIDRICQKFNVSYVDIVGEEKMLTPVEDYQLTLKIE
VIKERGAAILSELYRYQDSQGITFDDETSPWILMSDDLSDLINTKIYLVNTFDEVERYNGYLDGIERMLELANHQVVA

Nucleotide

• Length: 477 bp

>AT106881 NZ_CP030023:1224724-1225200 [Streptococcus suis]
ATGATTGGAGATAATATTAAATCGTTACGTAAAACCCATGATTTAACACAACCAGAATTCGCAAAGATTGTTGGAATTTC
TCGAAATAGTTTGAGCCGTTATGAAAATGGGACAAGCTCGTTATCAACAGAGCTCATAGACCGTATCTGTCAGAAATTTA
ATGTATCATATGTTGATATTGTAGGAGAAGAAAAAATGTTAACACCAGTGGAAGATTATCAATTAACCTTAAAAATTGAA
GTTATCAAAGAGCGTGGCGCAGCGATTTTGTCCGAACTATATCGCTATCAAGATAGTCAAGGAATTACTTTTGATGATGA
GACTAGCCCTTGGATTTTGATGAGTGATGATTTGTCTGATCTTATCAATACCAAGATTTACCTTGTCAATACTTTTGATG
AAGTGGAGCGTTACAATGGTTATTTAGATGGTATTGAGCGAATGTTGGAGCTTGCTAATCATCAGGTGGTGGCTTAA

Structures

Toxin

• AlphaFold DB: A0A0Z8INM2