Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 842645..843128 Replicon chromosome
Accession NZ_CP030023
Organism Streptococcus suis strain ISU2414

Toxin (Protein)


Gene name relE Uniprot ID A0A0Z8BIZ7
Locus tag DK877_RS04335 Protein ID WP_009910443.1
Coordinates 842868..843128 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag DK877_RS04330 Protein ID WP_012775256.1
Coordinates 842645..842866 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DK877_RS04300 838823..839263 + 441 WP_024409208.1 hypothetical protein -
DK877_RS04305 839333..839833 + 501 WP_024409209.1 hypothetical protein -
DK877_RS04310 839973..840359 + 387 WP_009910450.1 hypothetical protein -
DK877_RS04315 840543..840725 + 183 WP_009910449.1 type II toxin-antitoxin system HicA family toxin -
DK877_RS04320 840765..841217 + 453 WP_009910448.1 type II toxin-antitoxin system HicB family antitoxin -
DK877_RS04325 841329..841538 + 210 WP_009910447.1 hypothetical protein -
DK877_RS04330 842645..842866 + 222 WP_012775256.1 hypothetical protein Antitoxin
DK877_RS04335 842868..843128 + 261 WP_009910443.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DK877_RS04340 843295..843936 + 642 WP_002935700.1 HAD family hydrolase -
DK877_RS04345 843969..844154 - 186 WP_002935693.1 hypothetical protein -
DK877_RS04350 844218..845222 - 1005 WP_009910438.1 lactonase family protein -
DK877_RS04355 845358..846524 + 1167 WP_002935690.1 AI-2E family transporter -
DK877_RS04360 846514..847743 + 1230 WP_009910437.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - pavA 824374..857985 33611


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10270.78 Da        Isoelectric Point: 9.6925

>T106879 WP_009910443.1 NZ_CP030023:842868-843128 [Streptococcus suis]
MYHLEYSKKAQKQIKKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

>T106879 NZ_CP030023:842868-843128 [Streptococcus suis]
ATGTATCATTTAGAGTATTCTAAAAAGGCTCAAAAGCAAATTAAGAAATTAGATAGGCAAATTCAGAGGTTGTTGTTTGC
TTGGATTGATAAACACTTAGAAGGGACTGATAATCCACGCGCCAATGGTAAAGGTTTGACAGGCAATCATGCTAACGAGT
GGCGTTATCGTATCGGAGATTACCGACTGATTTGCGATATTCAAGATGATAAGTTGGTTATTTTAGCACTTGAGTTTGGA
CATCGTAAAGATGTCTATTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT106879 WP_012775256.1 NZ_CP030023:842645-842866 [Streptococcus suis]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp

>AT106879 NZ_CP030023:842645-842866 [Streptococcus suis]
ATGAGTACAGTGACAATCAGATTAAATCAAGAAGAAGAAGTATTCTTTAAAAGCTATGCACAATTAACAGGTCAAAGTCT
TTCTAGCCTTTTTAAGAAAGCTTTGGAGCGTGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCTTATGATG
AGTACAAAGCAGATCCAGAAACAATTAGTCATGCTGATTTTAAGAAAGAGCTAGGATTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8BIZ7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References