Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 840543..841217 Replicon chromosome
Accession NZ_CP030023
Organism Streptococcus suis strain ISU2414

Toxin (Protein)


Gene name hicA Uniprot ID A0A123U128
Locus tag DK877_RS04315 Protein ID WP_009910449.1
Coordinates 840543..840725 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A7Y6VEQ2
Locus tag DK877_RS04320 Protein ID WP_009910448.1
Coordinates 840765..841217 (+) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DK877_RS04265 835621..835824 + 204 WP_024409202.1 hypothetical protein -
DK877_RS04270 835817..836020 + 204 WP_024409203.1 hypothetical protein -
DK877_RS04275 836031..836297 + 267 WP_024409204.1 hypothetical protein -
DK877_RS04280 836308..836466 + 159 WP_162841287.1 hypothetical protein -
DK877_RS04285 836471..836686 + 216 WP_024409205.1 hypothetical protein -
DK877_RS04290 836700..837494 + 795 WP_079269917.1 DnaD domain protein -
DK877_RS04295 837510..838355 + 846 WP_024409207.1 ATP-binding protein -
DK877_RS04300 838823..839263 + 441 WP_024409208.1 hypothetical protein -
DK877_RS04305 839333..839833 + 501 WP_024409209.1 hypothetical protein -
DK877_RS04310 839973..840359 + 387 WP_009910450.1 hypothetical protein -
DK877_RS04315 840543..840725 + 183 WP_009910449.1 type II toxin-antitoxin system HicA family toxin Toxin
DK877_RS04320 840765..841217 + 453 WP_009910448.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
DK877_RS04325 841329..841538 + 210 WP_009910447.1 hypothetical protein -
DK877_RS04330 842645..842866 + 222 WP_012775256.1 hypothetical protein -
DK877_RS04335 842868..843128 + 261 WP_009910443.1 type II toxin-antitoxin system RelE/ParE family toxin -
DK877_RS04340 843295..843936 + 642 WP_002935700.1 HAD family hydrolase -
DK877_RS04345 843969..844154 - 186 WP_002935693.1 hypothetical protein -
DK877_RS04350 844218..845222 - 1005 WP_009910438.1 lactonase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - pavA 824374..857985 33611


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-82)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6681.93 Da        Isoelectric Point: 10.8207

>T106878 WP_009910449.1 NZ_CP030023:840543-840725 [Streptococcus suis]
MPMTQKEMVKLLTAHGWTKTKGGKGSHVKLEKVGERPITIPHGEINKYTERGIKKQAGLL

Download         Length: 183 bp

>T106878 NZ_CP030023:840543-840725 [Streptococcus suis]
ATGCCTATGACACAAAAAGAAATGGTTAAGCTACTTACCGCCCATGGTTGGACAAAAACTAAAGGTGGTAAGGGGTCTCA
CGTTAAACTTGAAAAAGTAGGCGAGCGACCTATAACCATTCCCCACGGTGAAATTAACAAATACACCGAAAGGGGTATCA
AAAAGCAAGCAGGGCTGTTATAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16672.68 Da        Isoelectric Point: 4.0098

>AT106878 WP_009910448.1 NZ_CP030023:840765-841217 [Streptococcus suis]
MLVTYPALFYYDDTDGATAPYFVTFPDFEHSATQGEDMADAMAMASDWLGIHLADYIENGRDIPTPTPINALSLADNNPF
RDDKDIELVYDPSKSFVSMVMVDVAEYLGSQEPVKKTLTIPRWADTLGRELGLNFSQTLTDAIADKKIHA

Download         Length: 453 bp

>AT106878 NZ_CP030023:840765-841217 [Streptococcus suis]
ATGCTTGTCACTTATCCAGCTTTATTTTATTATGACGATACAGACGGAGCTACCGCCCCTTATTTTGTCACTTTCCCAGA
CTTTGAACATTCAGCAACTCAGGGCGAAGATATGGCAGACGCTATGGCAATGGCTAGTGATTGGTTAGGTATTCATCTAG
CTGATTATATTGAGAATGGGCGTGATATTCCCACTCCTACCCCTATTAACGCTTTATCATTGGCTGATAATAACCCTTTC
CGTGATGATAAGGACATAGAGCTAGTTTATGACCCTAGCAAGTCTTTTGTATCTATGGTTATGGTTGACGTTGCTGAGTA
TCTAGGCAGTCAAGAGCCTGTAAAGAAAACACTAACTATTCCACGTTGGGCGGATACTTTAGGGCGTGAGTTAGGGCTAA
ATTTCTCACAGACCTTAACAGACGCTATTGCAGATAAGAAAATTCATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A123U128

Antitoxin

Source ID Structure
AlphaFold DB A0A7Y6VEQ2

References