Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 511777..512263 Replicon chromosome
Accession NZ_CP030023
Organism Streptococcus suis strain ISU2414

Toxin (Protein)


Gene name relE Uniprot ID D5AGV2
Locus tag DK877_RS02705 Protein ID WP_011922754.1
Coordinates 511994..512263 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AGV1
Locus tag DK877_RS02700 Protein ID WP_002938604.1
Coordinates 511777..512004 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DK877_RS02675 507109..507654 - 546 WP_009909618.1 NAD(P)H-dependent oxidoreductase -
DK877_RS02680 507717..508166 - 450 WP_009909619.1 MarR family transcriptional regulator -
DK877_RS02685 508469..508966 + 498 WP_002938611.1 DUF5590 domain-containing protein -
DK877_RS02690 508963..510144 + 1182 WP_002938610.1 pyridoxal phosphate-dependent aminotransferase -
DK877_RS02695 510159..511505 + 1347 WP_013730302.1 asparagine--tRNA ligase -
DK877_RS02700 511777..512004 + 228 WP_002938604.1 hypothetical protein Antitoxin
DK877_RS02705 511994..512263 + 270 WP_011922754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DK877_RS02710 512669..513988 + 1320 WP_002937278.1 MATE family efflux transporter -
DK877_RS02715 514172..514549 + 378 WP_013730303.1 RidA family protein -
DK877_RS02720 514571..515458 + 888 WP_002937261.1 RNase adapter RapZ -
DK877_RS02725 515455..516429 + 975 WP_002937257.1 YvcK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10437.49 Da        Isoelectric Point: 10.3916

>T106877 WP_011922754.1 NZ_CP030023:511994-512263 [Streptococcus suis]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK

Download         Length: 270 bp

>T106877 NZ_CP030023:511994-512263 [Streptococcus suis]
ATGGCTTATAAGCTTGTTCTCAGCGATGATGCTTTGAAGCAGTTGAAAAAAATGGACAGGCATGTGGGGATGATGCTTGC
TAAGGATTTGAAAAAACGTTTGGACGGTTTGGAGAATCCAAGACAATTTGGGAAGGCCTTGGTAGGAGACTATAAGGGGC
TGTGGCGGTATAGAGTGGGGAATTACCGTGTAATTTGTGATATTATTGATAACAAAATGGTCATCCTGGCCCTTGAAATC
GGGCACCGGAAAGAAATCTATAAAAAATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8450.51 Da        Isoelectric Point: 4.1589

>AT106877 WP_002938604.1 NZ_CP030023:511777-512004 [Streptococcus suis]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Download         Length: 228 bp

>AT106877 NZ_CP030023:511777-512004 [Streptococcus suis]
ATGGGAATTGTATCCTTGCGATTAAACGATGCAGAAGAAGAAATTTTCAGAAGCTATGCTATTCATACAGGAAAAAGCCT
GTCTGAGCTATTCAAAACTGCACTTGCTGAACAGATAGAAGACCAGTTGGACTATGAAATTGGTATCAAGGCTTTGAAGA
AATTCCAAGAAAATCCTGTTACACACTCGATTGATGATGTTCTTGCGGAGTTAGAAGATGGCTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126UKS2

Antitoxin

Source ID Structure
AlphaFold DB A0A140EXF0

References