Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/RelE(toxin) |
Location | 665582..666068 | Replicon | chromosome |
Accession | NZ_CP030022 | ||
Organism | Streptococcus suis strain ISU2714 |
Toxin (Protein)
Gene name | relE | Uniprot ID | D5AGV2 |
Locus tag | DK876_RS03295 | Protein ID | WP_011922754.1 |
Coordinates | 665799..666068 (+) | Length | 90 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | D5AGV1 |
Locus tag | DK876_RS03290 | Protein ID | WP_002938604.1 |
Coordinates | 665582..665809 (+) | Length | 76 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
DK876_RS03265 | 660625..661074 | - | 450 | WP_009909619.1 | MarR family transcriptional regulator | - |
DK876_RS03270 | 661368..662215 | + | 848 | WP_087892711.1 | IS630 family transposase | - |
DK876_RS03275 | 662274..662771 | + | 498 | WP_011922751.1 | DUF5590 domain-containing protein | - |
DK876_RS03280 | 662768..663949 | + | 1182 | WP_011922154.1 | pyridoxal phosphate-dependent aminotransferase | - |
DK876_RS03285 | 663964..665310 | + | 1347 | WP_011922752.1 | asparagine--tRNA ligase | - |
DK876_RS03290 | 665582..665809 | + | 228 | WP_002938604.1 | hypothetical protein | Antitoxin |
DK876_RS03295 | 665799..666068 | + | 270 | WP_011922754.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
DK876_RS03300 | 666474..667793 | + | 1320 | WP_012775027.1 | MATE family efflux transporter | - |
DK876_RS03305 | 667844..668221 | + | 378 | WP_002937263.1 | RidA family protein | - |
DK876_RS03310 | 668243..669130 | + | 888 | WP_011922160.1 | RNase adapter RapZ | - |
DK876_RS03315 | 669127..670101 | + | 975 | WP_002937257.1 | YvcK family protein | - |
DK876_RS03320 | 670098..671015 | + | 918 | WP_002937252.1 | DNA-binding protein WhiA | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 10437.49 Da Isoelectric Point: 10.3916
>T106872 WP_011922754.1 NZ_CP030022:665799-666068 [Streptococcus suis]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK
Download Length: 270 bp
>T106872 NZ_CP030022:665799-666068 [Streptococcus suis]
ATGGCTTATAAGCTTGTTCTCAGCGATGATGCTTTGAAGCAGTTGAAAAAAATGGACAGGCATGTGGGGATGATGCTTGC
TAAGGATTTGAAAAAACGTTTGGACGGTTTGGAGAATCCAAGACAATTTGGGAAGGCCTTGGTAGGAGACTATAAGGGGC
TGTGGCGGTATAGAGTGGGGAATTACCGTGTAATTTGTGATATTATTGATAACAAAATGGTCATCCTGGCCCTTGAAATC
GGGCACCGGAAAGAAATCTATAAAAAATGA
ATGGCTTATAAGCTTGTTCTCAGCGATGATGCTTTGAAGCAGTTGAAAAAAATGGACAGGCATGTGGGGATGATGCTTGC
TAAGGATTTGAAAAAACGTTTGGACGGTTTGGAGAATCCAAGACAATTTGGGAAGGCCTTGGTAGGAGACTATAAGGGGC
TGTGGCGGTATAGAGTGGGGAATTACCGTGTAATTTGTGATATTATTGATAACAAAATGGTCATCCTGGCCCTTGAAATC
GGGCACCGGAAAGAAATCTATAAAAAATGA
Antitoxin
Download Length: 76 a.a. Molecular weight: 8450.51 Da Isoelectric Point: 4.1589
>AT106872 WP_002938604.1 NZ_CP030022:665582-665809 [Streptococcus suis]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL
Download Length: 228 bp
>AT106872 NZ_CP030022:665582-665809 [Streptococcus suis]
ATGGGAATTGTATCCTTGCGATTAAACGATGCAGAAGAAGAAATTTTCAGAAGCTATGCTATTCATACAGGAAAAAGCCT
GTCTGAGCTATTCAAAACTGCACTTGCTGAACAGATAGAAGACCAGTTGGACTATGAAATTGGTATCAAGGCTTTGAAGA
AATTCCAAGAAAATCCTGTTACACACTCGATTGATGATGTTCTTGCGGAGTTAGAAGATGGCTTATAA
ATGGGAATTGTATCCTTGCGATTAAACGATGCAGAAGAAGAAATTTTCAGAAGCTATGCTATTCATACAGGAAAAAGCCT
GTCTGAGCTATTCAAAACTGCACTTGCTGAACAGATAGAAGACCAGTTGGACTATGAAATTGGTATCAAGGCTTTGAAGA
AATTCCAAGAAAATCCTGTTACACACTCGATTGATGATGTTCTTGCGGAGTTAGAAGATGGCTTATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A126UKS2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A140EXF0 |