106870

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) abiEi-abiEii/AbiEii-AbiEi
Location 604772..606204 Replicon chromosome
Accession NZ_CP030022
Organism Streptococcus suis strain ISU2714

Toxin (Protein)


Gene name abiEi Uniprot ID A0A0Z8TQK7
Locus tag DK876_RS02995 Protein ID WP_044475260.1
Coordinates 604772..605617 (-) Length 282 a.a.

Antitoxin (Protein)


Gene name abiEii Uniprot ID G7SFZ3
Locus tag DK876_RS03000 Protein ID WP_000037237.1
Coordinates 605614..606204 (-) Length 197 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DK876_RS02980 600340..603141 + 2802 WP_015445150.1 CHAP domain-containing protein -
DK876_RS02985 603278..604288 + 1011 WP_002936451.1 Abi family protein -
DK876_RS02990 604402..604686 + 285 Protein_540 CHAP domain-containing protein -
DK876_RS02995 604772..605617 - 846 WP_044475260.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
DK876_RS03000 605614..606204 - 591 WP_000037237.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
DK876_RS03005 606374..607534 + 1161 Protein_543 glucan-binding protein -
DK876_RS03010 607607..607690 + 84 WP_001814874.1 23S rRNA methyltransferase attenuation leader peptide -
DK876_RS03015 607815..608552 + 738 WP_001038795.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) -
DK876_RS03020 608722..608982 + 261 Protein_546 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
DK876_RS03025 609127..609273 + 147 WP_044475262.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element erm(B) / tet(O) tufA / neuB 483767..636465 152698


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(33-258)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(6-50)


Sequences

Toxin        


Download         Length: 282 a.a.        Molecular weight: 32395.98 Da        Isoelectric Point: 5.0544

>T106870 WP_044475260.1 NZ_CP030022:c605617-604772 [Streptococcus suis]
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSSYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHQITLSEE
TVKQQLKEILADSEEGISFVIQSITAIKESDDYGGYRATISCQLENIKQVIHLDIATGDVVTPQPITYDYKAIFDEDNFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKEDIDFIQLRNACQRTFSYRETELDFVKIIELLERFKSDP
IQNKQWQNYSKKYSYTKGISLADVLDEMISLITIIISTDSD

Download         Length: 846 bp

>T106870 NZ_CP030022:c605617-604772 [Streptococcus suis]
ATGAACAAAGCTAAATTAACAGCACTCTGTCATAAAATATCAAAGAATACTGGTTTAACCTTTAATTCCGTCATGACCTA
TTACTTCCTAGAAGTCATTTTGAAAAAATTAAGTCAAAGTTCTTATTCAAATCACTATATCTTCAAAGGAGGATTCCTAC
TTTCGAATGTCATCGGAGTTGAATCTCGTAGCACTGTTGATATTGACTTTTTATTCCATCAAATAACACTCTCAGAAGAA
ACTGTTAAACAGCAACTCAAGGAAATTTTAGCAGATTCCGAAGAAGGTATATCTTTTGTGATTCAATCAATCACAGCTAT
TAAAGAAAGTGATGACTATGGTGGCTATCGAGCAACAATTTCGTGCCAACTTGAGAATATTAAACAAGTTATCCATTTGG
ATATTGCGACAGGTGATGTTGTAACTCCTCAGCCGATTACATACGACTATAAAGCTATTTTTGATGAAGACAATTTTCCA
ATCATTGCTTATACAATTGAAACAATTCTAGCTGAAAAACTTCAAACCATCTATTCACGTAACTTCTTGAACAGTAGAAG
CAAAGATTTTTACGATGTTTATATTCTTTCCAAACTGAAGAAAGAAGACATTGACTTCATTCAGTTGAGAAATGCCTGTC
AGAGAACATTTTCATATCGCGAAACAGAACTCGATTTTGTAAAGATTATTGAACTACTCGAGAGGTTCAAATCTGACCCT
ATTCAGAATAAACAATGGCAAAATTATTCAAAAAAATATAGCTATACAAAAGGGATTTCACTTGCAGATGTTCTTGATGA
GATGATTAGTCTTATTACAATTATTATTTCTACTGACTCTGATTAA

Antitoxin


Download         Length: 197 a.a.        Molecular weight: 23056.59 Da        Isoelectric Point: 7.8056

>AT106870 WP_000037237.1 NZ_CP030022:c606204-605614 [Streptococcus suis]
MSKKEILLDFIEKNNGIVTNKDCKALGIPTIYLTRLEKEGIIFRVEKGIFLTQNGDYDEYYFFQYRFPKAIFSYISALYL
QQFTDEIPQYFDVTVPRGYRFNTPPANLNIHFVSKEYSELGMTTVPTPLGNNVRVYDFERIICDFVIHREKIDSELFVKT
LQSYGNYPKKNLAKLYEYATKMNTLEKVKQTLEVLI

Download         Length: 591 bp

>AT106870 NZ_CP030022:c606204-605614 [Streptococcus suis]
ATGTCAAAAAAAGAGATTCTACTCGATTTTATAGAAAAGAACAATGGAATTGTCACAAACAAAGATTGTAAAGCACTAGG
TATTCCAACAATATATCTGACAAGACTAGAGAAAGAAGGCATTATCTTCCGAGTTGAAAAAGGTATTTTCCTAACCCAAA
ACGGAGACTATGATGAATACTACTTCTTTCAATATCGTTTTCCTAAGGCTATTTTCTCTTATATTTCGGCACTGTATCTA
CAACAGTTTACAGATGAAATTCCACAATATTTTGATGTGACAGTTCCTAGAGGCTACCGCTTTAATACTCCTCCAGCTAA
TCTAAATATTCACTTTGTCTCTAAAGAATACAGCGAGCTGGGAATGACTACTGTACCTACTCCTTTGGGAAACAACGTAA
GGGTATATGATTTTGAACGTATTATTTGTGATTTTGTAATACATCGAGAAAAGATTGATTCCGAACTCTTTGTCAAGACA
CTTCAATCTTATGGGAACTATCCTAAAAAAAATCTAGCAAAACTCTATGAATATGCGACAAAAATGAATACTTTAGAAAA
AGTTAAACAAACTCTGGAGGTTCTAATATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8TQK7

Antitoxin

Source ID Structure
AlphaFold DB G7SFZ3

References