Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-couple_hipB
Location 981189..982432 Replicon chromosome
Accession NZ_CP030020
Organism Streptococcus suis strain ISU2514

Toxin (Protein)


Gene name pezA Uniprot ID A0A8D4CZB7
Locus tag DK875_RS04755 Protein ID WP_002935066.1
Coordinates 981189..981956 (-) Length 256 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID -
Locus tag DK875_RS04760 Protein ID WP_002935067.1
Coordinates 981956..982432 (-) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DK875_RS04740 977577..977942 - 366 WP_002935058.1 MobC family plasmid mobilization relaxosome protein -
DK875_RS04745 977952..978311 - 360 WP_002935059.1 hypothetical protein -
DK875_RS04750 978646..981153 - 2508 WP_053866460.1 AAA family ATPase -
DK875_RS04755 981189..981956 - 768 WP_002935066.1 zeta toxin family protein Toxin
DK875_RS04760 981956..982432 - 477 WP_002935067.1 helix-turn-helix domain-containing protein Antitoxin
DK875_RS04765 982502..982792 - 291 WP_002935069.1 hypothetical protein -
DK875_RS04770 982842..983231 - 390 WP_002935071.1 hypothetical protein -
DK875_RS04775 983228..983455 - 228 WP_002935073.1 hypothetical protein -
DK875_RS04780 983509..984585 - 1077 WP_002935075.1 toprim domain-containing protein -
DK875_RS04785 984648..986504 - 1857 WP_001820670.1 recombinase family protein -
DK875_RS04790 986559..986750 - 192 WP_001820669.1 hypothetical protein -
DK875_RS04795 986822..987052 - 231 WP_001206986.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element tet(O) - 967099..1024398 57299


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(28-214)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 256 a.a.        Molecular weight: 28956.86 Da        Isoelectric Point: 5.6977

>T106867 WP_002935066.1 NZ_CP030020:c981956-981189 [Streptococcus suis]
MRLEEFSEAEFQKALQRTIRALTRGKTIPGQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEHLVDGLSTQGYHLLIEGTLRTTQVPRQTAQLLVSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPNQARATPKEHHDGIVENLVDNLRELEREQLFDQIQIYQRDRTCIYDSAIDEGSAAEVLQECLFGKWSKVEEEMV
KESELLLNELLEKNK

Download         Length: 768 bp

>T106867 NZ_CP030020:c981956-981189 [Streptococcus suis]
ATGAGGTTGGAAGAATTCAGTGAGGCTGAGTTTCAGAAGGCCTTACAGCGAACCATTCGGGCCTTAACCCGAGGAAAGAC
GATTCCAGGTCAACCGAAAGCTATCTTGCTTGGTGGACAAAGCGGAGCAGGTAAGACGACTATTCATCGTATCAAGCAAA
AAGAATTTCAAGGCAATATCATTATCATCGATGGTGATAGCTACCGTTCTCAGCATCCCAACTACTTAGCCCTGCAAGAA
AAGTATGGCAAGGACAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAGCATCTGGTTGACGGACTCAGCAC
GCAGGGGTATCACTTGCTGATTGAGGGAACTTTGCGAACCACTCAAGTTCCTCGTCAGACTGCTCAATTATTAGTATCAA
AAGGCTACCAGGTTTCCTTAGCTGTGATTGGCACCAAACCAGAATTGTCCTATCTCAGTACTTTGATTCGTTACGAAGAG
CTTTATGCCATCGATCCCAATCAGGCCAGAGCAACGCCAAAAGAACACCATGATGGGATTGTAGAGAACTTGGTTGATAA
CCTAAGGGAGTTAGAAAGAGAGCAACTCTTTGACCAGATTCAGATTTATCAAAGAGACAGGACTTGCATTTATGATTCTG
CAATTGATGAAGGCTCCGCAGCAGAAGTGTTACAAGAGTGTCTCTTTGGAAAATGGAGCAAGGTAGAGGAGGAGATGGTG
AAGGAGAGTGAACTCCTACTTAATGAATTACTTGAGAAAAATAAATAA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18273.67 Da        Isoelectric Point: 4.3971

>AT106867 WP_002935067.1 NZ_CP030020:c982432-981956 [Streptococcus suis]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYQLTLKVE
VIKERGAAILSQLYRYQDSQDIAFDDESNPWILMSDDLAELINTKIYLVDTFDEIERYNGYLDGIERMLDMVHHRVVA

Download         Length: 477 bp

>AT106867 NZ_CP030020:c982432-981956 [Streptococcus suis]
ATGATTGGAGACAATATCAAGTCGCTACGCCGAACACATGATTTAACACAACCAGAATTTGCGAAAATGGTTGGTATTTC
ACGCAATAGCTTAAGTCGTTATGAAAATGGGACTAGTACAGTTTCAACTGAACTCATCGACCGTATTTGTCAGAAATTTA
ACGTTTCTTATGTCGATATTGTAGGGGAGGATAAGATGTTAACACCTGTTGAAGATTACCAACTGACTTTAAAAGTAGAA
GTGATAAAAGAACGTGGAGCTGCCATTTTATCACAGCTTTATAGATACCAGGATAGTCAAGATATTGCTTTTGATGATGA
ATCCAACCCTTGGATTTTGATGAGTGATGACTTGGCCGAATTGATTAACACAAAAATTTACCTTGTCGATACTTTCGATG
AAATAGAGCGTTACAATGGCTATTTAGACGGTATCGAGCGGATGTTAGACATGGTGCATCATCGGGTGGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References