Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 710244..710730 Replicon chromosome
Accession NZ_CP030020
Organism Streptococcus suis strain ISU2514

Toxin (Protein)


Gene name relE Uniprot ID D5AGV2
Locus tag DK875_RS03485 Protein ID WP_011922754.1
Coordinates 710461..710730 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AGV1
Locus tag DK875_RS03480 Protein ID WP_002938604.1
Coordinates 710244..710471 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DK875_RS03455 705576..706121 - 546 WP_002938614.1 NAD(P)H-dependent oxidoreductase -
DK875_RS03460 706184..706633 - 450 WP_002938613.1 MarR family transcriptional regulator -
DK875_RS03465 706936..707433 + 498 WP_002938611.1 DUF5590 domain-containing protein -
DK875_RS03470 707430..708611 + 1182 WP_002938610.1 pyridoxal phosphate-dependent aminotransferase -
DK875_RS03475 708626..709972 + 1347 WP_013730302.1 asparagine--tRNA ligase -
DK875_RS03480 710244..710471 + 228 WP_002938604.1 hypothetical protein Antitoxin
DK875_RS03485 710461..710730 + 270 WP_011922754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DK875_RS03490 711136..712455 + 1320 WP_053866466.1 MATE family efflux transporter -
DK875_RS03495 712639..713016 + 378 WP_002937263.1 RidA family protein -
DK875_RS03500 713038..713925 + 888 WP_002937261.1 RNase adapter RapZ -
DK875_RS03505 713922..714896 + 975 WP_002937257.1 YvcK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10437.49 Da        Isoelectric Point: 10.3916

>T106865 WP_011922754.1 NZ_CP030020:710461-710730 [Streptococcus suis]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK

Download         Length: 270 bp

>T106865 NZ_CP030020:710461-710730 [Streptococcus suis]
ATGGCTTATAAGCTTGTTCTCAGCGATGATGCTTTGAAGCAGTTGAAAAAAATGGACAGGCATGTGGGGATGATGCTTGC
TAAGGATTTGAAAAAACGTTTGGACGGTTTGGAGAATCCAAGACAATTTGGGAAGGCCTTGGTAGGAGACTATAAGGGGC
TGTGGCGGTATAGAGTGGGGAATTACCGTGTAATTTGTGATATTATTGATAACAAAATGGTCATCCTGGCCCTTGAAATC
GGGCACCGGAAAGAAATCTATAAAAAATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8450.51 Da        Isoelectric Point: 4.1589

>AT106865 WP_002938604.1 NZ_CP030020:710244-710471 [Streptococcus suis]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Download         Length: 228 bp

>AT106865 NZ_CP030020:710244-710471 [Streptococcus suis]
ATGGGAATTGTATCCTTGCGATTAAACGATGCAGAAGAAGAAATTTTCAGAAGCTATGCTATTCATACAGGAAAAAGCCT
GTCTGAGCTATTCAAAACTGCACTTGCTGAACAGATAGAAGACCAGTTGGACTATGAAATTGGTATCAAGGCTTTGAAGA
AATTCCAAGAAAATCCTGTTACACACTCGATTGATGATGTTCTTGCGGAGTTAGAAGATGGCTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126UKS2

Antitoxin

Source ID Structure
AlphaFold DB A0A140EXF0

References