Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-couple_hipB
Location 892064..893322 Replicon chromosome
Accession NZ_CP030017
Organism Streptococcus suis strain ISU1606

Toxin (Protein)


Gene name sezT Uniprot ID -
Locus tag DK235_RS04370 Protein ID WP_053865956.1
Coordinates 892064..892846 (-) Length 261 a.a.

Antitoxin (Protein)


Gene name sezA Uniprot ID -
Locus tag DK235_RS04375 Protein ID WP_000578719.1
Coordinates 892846..893322 (-) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DK235_RS04350 888114..888479 - 366 WP_053865954.1 MobC family plasmid mobilization relaxosome protein -
DK235_RS04355 888489..888848 - 360 WP_000529541.1 hypothetical protein -
DK235_RS04360 889229..890848 - 1620 WP_053865955.1 ATP-binding protein -
DK235_RS04365 890838..892067 - 1230 WP_024380477.1 SIR2 family protein -
DK235_RS04370 892064..892846 - 783 WP_053865956.1 zeta toxin family protein Toxin
DK235_RS04375 892846..893322 - 477 WP_000578719.1 helix-turn-helix domain-containing protein Antitoxin
DK235_RS04380 893392..893682 - 291 WP_000667951.1 hypothetical protein -
DK235_RS04385 893698..894087 - 390 WP_000048066.1 hypothetical protein -
DK235_RS04390 894084..894311 - 228 WP_000110922.1 hypothetical protein -
DK235_RS04395 894339..895439 - 1101 WP_000196860.1 toprim domain-containing protein -
DK235_RS04400 895479..896117 - 639 WP_053865957.1 hypothetical protein -
DK235_RS04405 896212..896502 - 291 WP_000893083.1 hypothetical protein -
DK235_RS04410 896516..896815 - 300 WP_017767994.1 hypothetical protein -
DK235_RS04415 896886..897845 - 960 Protein_822 helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element tet(O/32/O) / erm(B) - 873102..939658 66556


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(28-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 261 a.a.        Molecular weight: 29660.57 Da        Isoelectric Point: 6.3598

>T106859 WP_053865956.1 NZ_CP030017:c892846-892064 [Streptococcus suis]
MRLEEFSEAEFQKALQRTIRALTRGKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEQLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLSSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPTQARATPKEHHDGIVENLVDNLRELESDKLFDRIQIYQRDRSCIYDSETDEGSAAEVLQNCLFGKWSKVEEEML
QIEKDRLKRLYKVKENGNSL

Download         Length: 783 bp

>T106859 NZ_CP030017:c892846-892064 [Streptococcus suis]
ATGAGACTGGAAGAATTTAGTGAGGCTGAGTTTCAGAAGGCCTTGCAGCGAACCATTCGGGCCTTAACCCGAGGAAAGAC
GATTCCAGATCAACCGAAAGCTATCTTGCTTGGTGGACAAAGCGGAGCAGGTAAGACGACTATTCATCGTATCAAGCAAA
AGGAATTTCAAGGTAATATCATTATTATCGATGGTGACAGCTACCGTTCTCAGCATCCCAATTACTTAGCCCTGCAAGAA
AAGTATGGCAAGGATAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAACAGTTGGTTGATGAACTCAGTAC
GCAAGGCTACCATTTGCTGATTGAGGGAACCTTGCGAACTACTCAAGTTCCTCGTCAGACTGCTCAATTATTATCTTCTA
AAGGTTACCAAGTTTCCTTAGCAGTGATTGGTACCAAACCAGAGCTTTCTTATCTCAGCACCTTGATTCGTTACGAAGAG
CTTTATGCCATCGATCCGACTCAGGCCAGAGCAACGCCAAAAGAACACCATGATGGGATTGTAGAGAACTTGGTTGATAA
CTTGAGGGAGTTAGAAAGTGATAAACTCTTTGACCGCATTCAAATTTATCAAAGAGATAGGAGTTGTATCTACGATTCTG
AAACAGATGAAGGTTCCGCAGCAGAGGTTCTTCAAAACTGTCTTTTCGGGAAGTGGAGTAAAGTTGAGGAAGAGATGTTG
CAAATAGAGAAAGATAGATTAAAAAGGCTATATAAAGTTAAGGAGAATGGAAATAGTTTATGA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18266.77 Da        Isoelectric Point: 4.6424

>AT106859 WP_000578719.1 NZ_CP030017:c893322-892846 [Streptococcus suis]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYHLTLKVE
VIKERGAAILSKLYRYQDSQDIVFDDESNPWILMSDDLAELINTKIYLVATFDEIERYNGYLDGIERMLDMVHHRVVA

Download         Length: 477 bp

>AT106859 NZ_CP030017:c893322-892846 [Streptococcus suis]
ATGATCGGAGACAATATAAAATCACTACGCCGAACACACGATTTAACACAGCCAGAATTTGCGAAAATGGTTGGGATTTC
ACGCAATAGCCTGAGTCGCTACGAAAATGGTACCAGCACTGTTTCAACTGAACTCATCGACCGTATTTGTCAGAAATTTA
ACGTTTCTTATGTCGATATTGTAGGAGAGGACAAGATGTTAACACCTGTCGAAGATTACCATCTGACTTTAAAAGTAGAA
GTGATAAAAGAACGTGGAGCAGCCATTTTATCAAAGCTTTATAGATACCAGGATAGTCAAGATATTGTTTTTGATGATGA
ATCTAATCCTTGGATTTTGATGAGTGATGACTTGGCCGAATTGATCAATACGAAAATTTACCTTGTCGCTACTTTCGATG
AAATAGAGCGTTACAATGGCTATTTAGATGGTATAGAGCGGATGTTAGACATGGTGCATCATCGGGTGGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References