Detailed information of TA system TA106859

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): omega-epsilon-zeta/zeta-couple_hipB
• Location: 892064..893322
• Replicon: chromosome
• Accession: NZ_CP030017
• Organism: Streptococcus suis strain ISU1606

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: -
• Locus tag: DK235_RS04370
• Protein ID: WP_053865956.1
• Coordinates: 892064..892846 (-)
• Length: 261 a.a.

Antitoxin (Protein)

• Gene name: sezA
• Uniprot ID: -
• Locus tag: DK235_RS04375
• Protein ID: WP_000578719.1
• Coordinates: 892846..893322 (-)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DK235_RS04350	888114..888479	-	366	WP_053865954.1	MobC family plasmid mobilization relaxosome protein	-
DK235_RS04355	888489..888848	-	360	WP_000529541.1	hypothetical protein	-
DK235_RS04360	889229..890848	-	1620	WP_053865955.1	ATP-binding protein	-
DK235_RS04365	890838..892067	-	1230	WP_024380477.1	SIR2 family protein	-
DK235_RS04370	892064..892846	-	783	WP_053865956.1	zeta toxin family protein	Toxin
DK235_RS04375	892846..893322	-	477	WP_000578719.1	helix-turn-helix domain-containing protein	Antitoxin
DK235_RS04380	893392..893682	-	291	WP_000667951.1	hypothetical protein	-
DK235_RS04385	893698..894087	-	390	WP_000048066.1	hypothetical protein	-
DK235_RS04390	894084..894311	-	228	WP_000110922.1	hypothetical protein	-
DK235_RS04395	894339..895439	-	1101	WP_000196860.1	toprim domain-containing protein	-
DK235_RS04400	895479..896117	-	639	WP_053865957.1	hypothetical protein	-
DK235_RS04405	896212..896502	-	291	WP_000893083.1	hypothetical protein	-
DK235_RS04410	896516..896815	-	300	WP_017767994.1	hypothetical protein	-
DK235_RS04415	896886..897845	-	960	Protein_822	helicase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	tet(O/32/O) / erm(B)	-	873102..939658	66556

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (28-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 261 a.a.
• Molecular weight: 29660.57 Da
• Isoelectric Point: 6.3598

>T106859 WP_053865956.1 NZ_CP030017:c892846-892064 [Streptococcus suis]
MRLEEFSEAEFQKALQRTIRALTRGKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEQLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLSSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPTQARATPKEHHDGIVENLVDNLRELESDKLFDRIQIYQRDRSCIYDSETDEGSAAEVLQNCLFGKWSKVEEEML
QIEKDRLKRLYKVKENGNSL

Nucleotide

• Length: 783 bp

>T106859 NZ_CP030017:c892846-892064 [Streptococcus suis]
ATGAGACTGGAAGAATTTAGTGAGGCTGAGTTTCAGAAGGCCTTGCAGCGAACCATTCGGGCCTTAACCCGAGGAAAGAC
GATTCCAGATCAACCGAAAGCTATCTTGCTTGGTGGACAAAGCGGAGCAGGTAAGACGACTATTCATCGTATCAAGCAAA
AGGAATTTCAAGGTAATATCATTATTATCGATGGTGACAGCTACCGTTCTCAGCATCCCAATTACTTAGCCCTGCAAGAA
AAGTATGGCAAGGATAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAACAGTTGGTTGATGAACTCAGTAC
GCAAGGCTACCATTTGCTGATTGAGGGAACCTTGCGAACTACTCAAGTTCCTCGTCAGACTGCTCAATTATTATCTTCTA
AAGGTTACCAAGTTTCCTTAGCAGTGATTGGTACCAAACCAGAGCTTTCTTATCTCAGCACCTTGATTCGTTACGAAGAG
CTTTATGCCATCGATCCGACTCAGGCCAGAGCAACGCCAAAAGAACACCATGATGGGATTGTAGAGAACTTGGTTGATAA
CTTGAGGGAGTTAGAAAGTGATAAACTCTTTGACCGCATTCAAATTTATCAAAGAGATAGGAGTTGTATCTACGATTCTG
AAACAGATGAAGGTTCCGCAGCAGAGGTTCTTCAAAACTGTCTTTTCGGGAAGTGGAGTAAAGTTGAGGAAGAGATGTTG
CAAATAGAGAAAGATAGATTAAAAAGGCTATATAAAGTTAAGGAGAATGGAAATAGTTTATGA

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18266.77 Da
• Isoelectric Point: 4.6424

>AT106859 WP_000578719.1 NZ_CP030017:c893322-892846 [Streptococcus suis]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYHLTLKVE
VIKERGAAILSKLYRYQDSQDIVFDDESNPWILMSDDLAELINTKIYLVATFDEIERYNGYLDGIERMLDMVHHRVVA

Nucleotide

• Length: 477 bp

>AT106859 NZ_CP030017:c893322-892846 [Streptococcus suis]
ATGATCGGAGACAATATAAAATCACTACGCCGAACACACGATTTAACACAGCCAGAATTTGCGAAAATGGTTGGGATTTC
ACGCAATAGCCTGAGTCGCTACGAAAATGGTACCAGCACTGTTTCAACTGAACTCATCGACCGTATTTGTCAGAAATTTA
ACGTTTCTTATGTCGATATTGTAGGAGAGGACAAGATGTTAACACCTGTCGAAGATTACCATCTGACTTTAAAAGTAGAA
GTGATAAAAGAACGTGGAGCAGCCATTTTATCAAAGCTTTATAGATACCAGGATAGTCAAGATATTGTTTTTGATGATGA
ATCTAATCCTTGGATTTTGATGAGTGATGACTTGGCCGAATTGATCAATACGAAAATTTACCTTGTCGCTACTTTCGATG
AAATAGAGCGTTACAATGGCTATTTAGATGGTATAGAGCGGATGTTAGACATGGTGCATCATCGGGTGGTGGCTTAA