Detailed information of TA system TA106858

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 859294..859786
• Replicon: chromosome
• Accession: NZ_CP030017
• Organism: Streptococcus suis strain ISU1606

Toxin (Protein)

• Gene name: relE
• Uniprot ID: D5AHJ6
• Locus tag: DK235_RS04200
• Protein ID: WP_011922404.1
• Coordinates: 859294..859551 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: DK235_RS04205
• Protein ID: WP_053865951.1
• Coordinates: 859535..859786 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DK235_RS04180	854928..855998	+	1071	WP_012775101.1	tyrosine recombinase XerS	-
DK235_RS04185	856068..857576	-	1509	WP_011922400.1	phosphomannomutase/phosphoglucomutase	-
DK235_RS04190	857652..858593	-	942	WP_012775102.1	sensor histidine kinase	-
DK235_RS04195	858590..859255	-	666	WP_012775103.1	response regulator transcription factor	-
DK235_RS04200	859294..859551	-	258	WP_011922404.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DK235_RS04205	859535..859786	-	252	WP_053865951.1	hypothetical protein	Antitoxin
DK235_RS04210	859878..861848	-	1971	WP_012775105.1	FtsX-like permease family protein	-
DK235_RS04215	861849..862601	-	753	WP_011922409.1	ABC transporter ATP-binding protein	-
DK235_RS04220	862737..863471	-	735	WP_011922410.1	ABC transporter permease	-
DK235_RS04225	863473..864219	-	747	WP_011922411.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (10-75)

Antitoxin

• Protein of unknown function DUF6290 (1-75)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9981.62 Da
• Isoelectric Point: 10.8924

>T106858 WP_011922404.1 NZ_CP030017:c859551-859294 [Streptococcus suis]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI

Nucleotide

• Length: 258 bp

>T106858 NZ_CP030017:c859551-859294 [Streptococcus suis]
ATGAAGACCTGTTATAAACTCGTACCGACCAGTCGTTTTATTAAACAGTTGAAAAAGTTGGACAAATTTACCCAAAAACA
GATTACCAACTACTTGTCCAGTCATGTGACTGACAACCCTAGACAATACGGAAAAGCCTTGACTGCTAATCGTTCTGGCC
AATGGCGCTATCGTATCGGCAATTACAGGGTTATCGTTAATATTGAAGATGATAAATTGATTGTGACAAGCATAAAAATG
AGAAATGGAAGTATATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9355.61 Da
• Isoelectric Point: 3.6767

>AT106858 WP_053865951.1 NZ_CP030017:c859786-859535 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIWTKTLEALEDEYDARVADIALSEYEADLAKGIEPISWEEMLEELGLTDE
DLL

Nucleotide

• Length: 252 bp

>AT106858 NZ_CP030017:c859786-859535 [Streptococcus suis]
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGTTT
GTCAGAACTCATTTGGACTAAAACCCTTGAAGCTCTCGAAGATGAATATGATGCCCGTGTGGCAGATATCGCTCTGTCTG
AATACGAGGCAGACTTGGCGAAAGGCATTGAGCCGATTAGCTGGGAGGAAATGTTGGAAGAGTTGGGGTTGACGGATGAA
GACCTGTTATAA

Structures

Toxin

• AlphaFold DB: A0A0Z8U747