Detailed information of TA system TA106855

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): shpAB/BrnT-BrnA
• Location: 4298336..4298912
• Replicon: chromosome
• Accession: NZ_CP030007
• Organism: Enterobacter hormaechei subsp. xiangfangensis strain Pb204

Toxin (Protein)

• Gene name: shpA
• Uniprot ID: A0A800YKM1
• Locus tag: DN066_RS21110
• Protein ID: WP_015572580.1
• Coordinates: 4298625..4298912 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: shpB
• Uniprot ID: -
• Locus tag: DN066_RS21105
• Protein ID: WP_111533417.1
• Coordinates: 4298336..4298638 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DN066_RS21085	4294631..4295176	+	546	WP_006810254.1	porin	-
DN066_RS21090	4295354..4296724	-	1371	WP_032647147.1	NAD-dependent succinate-semialdehyde dehydrogenase	-
DN066_RS21095	4296878..4297630	+	753	WP_015572582.1	AraC family transcriptional regulator	-
DN066_RS21100	4297669..4298307	+	639	WP_032647144.1	LysE family translocator	-
DN066_RS21105	4298336..4298638	-	303	WP_111533417.1	BrnA antitoxin family protein	Antitoxin
DN066_RS21110	4298625..4298912	-	288	WP_015572580.1	BrnT family toxin	Toxin
DN066_RS21115	4299081..4300352	+	1272	WP_032647142.1	DUF445 domain-containing protein	-
DN066_RS21120	4300349..4301425	-	1077	WP_015572578.1	DUF2955 domain-containing protein	-
DN066_RS21125	4301415..4302482	-	1068	WP_026094404.1	HlyD family secretion protein	-
DN066_RS21130	4302479..4302949	-	471	WP_032647140.1	MarR family transcriptional regulator	-
DN066_RS21135	4303099..4303794	-	696	WP_032647138.1	winged helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (7-88)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (37-93)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11296.81 Da
• Isoelectric Point: 7.3587

>T106855 WP_015572580.1 NZ_CP030007:c4298912-4298625 [Enterobacter hormaechei subsp. xiangfangensis]
MPIEYEWDSNKAKSNLQKHAIRFEDAVLVFDDPCHLSVQDRYENGEFRWQTIGLVQGVIVILVAHTVRFESGDEIIRIIS
ARKADRKERRRYEHR

Nucleotide

• Length: 288 bp

>T106855 NZ_CP030007:c4298912-4298625 [Enterobacter hormaechei subsp. xiangfangensis]
ATGCCTATAGAGTATGAATGGGATAGCAATAAGGCGAAAAGCAATCTGCAAAAACACGCCATTCGTTTTGAAGATGCAGT
TCTGGTTTTTGACGATCCCTGCCATTTGTCTGTTCAGGATCGTTATGAAAACGGGGAGTTTCGCTGGCAAACCATTGGTC
TTGTACAGGGTGTTATTGTCATTCTGGTCGCGCACACGGTACGTTTTGAAAGCGGGGATGAAATCATACGTATCATCAGT
GCGCGTAAAGCGGATCGTAAAGAGAGGAGGCGTTATGAGCATCGTTAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11455.06 Da
• Isoelectric Point: 10.2864

>AT106855 WP_111533417.1 NZ_CP030007:c4298638-4298336 [Enterobacter hormaechei subsp. xiangfangensis]
MSIVKHKRGSAPEVSARREAELKALADTPDREIDYSDIPATEDDRWAGAVRGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Nucleotide

• Length: 303 bp

>AT106855 NZ_CP030007:c4298638-4298336 [Enterobacter hormaechei subsp. xiangfangensis]
ATGAGCATCGTTAAACATAAACGCGGTAGTGCACCGGAAGTGAGTGCCCGCCGGGAGGCTGAACTCAAAGCGCTGGCGGA
TACACCCGACAGGGAAATTGATTACAGCGATATACCGGCCACGGAGGATGATCGCTGGGCCGGTGCCGTGCGGGGAAAAT
TCTATCGACCGCTCAAAACTCAGGCATCAGTACGCATTGACGCCGACGTGATGGAGTGGCTTAAACGGCCAGGGAAAGGT
TACCAGACGCGGCTTAATGCCATTTTGCGCGAGGCGATGCTGCGCGATCAGAACAAAAAATAA