Detailed information of TA system TA106854

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 3929289..3930004
• Replicon: chromosome
• Accession: NZ_CP030007
• Organism: Enterobacter hormaechei subsp. xiangfangensis strain Pb204

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: A0A8I0UM05
• Locus tag: DN066_RS19265
• Protein ID: WP_023303149.1
• Coordinates: 3929289..3929657 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: A0A8I0UJV2
• Locus tag: DN066_RS19270
• Protein ID: WP_023303148.1
• Coordinates: 3929678..3930004 (-)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DN066_RS19240	3925216..3925710	+	495	WP_023295996.1	hypothetical protein	-
DN066_RS19245	3925728..3927665	+	1938	WP_032647366.1	bifunctional diguanylate cyclase/phosphodiesterase	-
DN066_RS19255	3927925..3928182	+	258	WP_003863178.1	YjhX family toxin	-
DN066_RS19260	3928193..3928939	+	747	WP_032647364.1	class I SAM-dependent methyltransferase	-
DN066_RS19265	3929289..3929657	-	369	WP_023303149.1	TA system toxin CbtA family protein	Toxin
DN066_RS19270	3929678..3930004	-	327	WP_023303148.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
DN066_RS19275	3930017..3930487	-	471	WP_023303147.1	DNA repair protein RadC	-
DN066_RS19280	3930553..3931374	-	822	WP_023303146.1	DUF945 domain-containing protein	-
DN066_RS19290	3932064..3932903	-	840	WP_023303145.1	hypothetical protein	-
DN066_RS19295	3932962..3933396	-	435	WP_023303144.1	hypothetical protein	-
DN066_RS19300	3933705..3934970	-	1266	WP_045324920.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-111)

Antitoxin

• Antitoxin CbeA (7-107)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13727.91 Da
• Isoelectric Point: 8.2822

>T106854 WP_023303149.1 NZ_CP030007:c3929657-3929289 [Enterobacter hormaechei subsp. xiangfangensis]
MKNLPATISRAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGIILADAVNFLVDKYELVRIDRRGF
SSQGQVPYLTVTDILHARRACGLMKSCSYREVSNIVLSHSRQ

Nucleotide

• Length: 369 bp

>T106854 NZ_CP030007:c3929657-3929289 [Enterobacter hormaechei subsp. xiangfangensis]
ATGAAAAATCTACCTGCTACAATTTCGCGGGCGGCGAAGCCCTGCCTGTCGCCCGTTGCAGTCTGGCAAATGTTACTTAC
TCGTCTGCTTGAACAGCACTATGGTCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTAATTAAGGAACATATTG
ATGCTGGGATTATCCTGGCCGATGCAGTCAACTTCCTGGTAGATAAGTACGAACTGGTTCGCATTGATCGCAGAGGATTT
AGCTCACAGGGACAAGTACCATATTTGACCGTGACAGATATCCTTCATGCCAGAAGAGCATGTGGATTAATGAAAAGTTG
CTCTTATCGGGAAGTAAGTAATATTGTTCTTAGTCATTCGCGGCAGTGA

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 12215.04 Da
• Isoelectric Point: 7.0266

>AT106854 WP_023303148.1 NZ_CP030007:c3930004-3929678 [Enterobacter hormaechei subsp. xiangfangensis]
MSLIPAHEWGIKSDIVPRLGVRLVQEGNRLHYLADRASITGKFSDAECLKLDIVFPHFIRQMESMLTTGEMNSRHAHCVT
LYHNGFTCEADTLGSCGYVYIAIYPTQR

Nucleotide

• Length: 327 bp

>AT106854 NZ_CP030007:c3930004-3929678 [Enterobacter hormaechei subsp. xiangfangensis]
ATGTCATTAATACCAGCCCATGAATGGGGGATAAAAAGCGATATTGTTCCACGGCTTGGAGTCAGATTAGTTCAGGAAGG
CAACCGGCTGCACTATCTGGCTGACCGGGCTAGTATCACCGGTAAGTTCAGTGACGCCGAATGCCTGAAGTTGGATATCG
TATTTCCGCATTTTATCCGTCAGATGGAATCGATGCTGACCACTGGTGAAATGAATTCTCGCCATGCCCACTGTGTCACT
CTGTACCACAACGGTTTCACCTGCGAAGCCGATACCCTTGGTAGTTGCGGCTACGTATACATCGCCATTTATCCCACTCA
ACGCTAA