Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2569104..2569843 Replicon chromosome
Accession NZ_CP030007
Organism Enterobacter hormaechei subsp. xiangfangensis strain Pb204

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag DN066_RS12585 Protein ID WP_003857133.1
Coordinates 2569358..2569843 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag DN066_RS12580 Protein ID WP_003857131.1
Coordinates 2569104..2569370 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DN066_RS12560 2564586..2565572 + 987 WP_017382341.1 DUF979 domain-containing protein -
DN066_RS12565 2565582..2566577 + 996 WP_017382342.1 DUF2891 domain-containing protein -
DN066_RS12570 2566599..2567981 - 1383 WP_032648336.1 MFS transporter -
DN066_RS12575 2568111..2569040 + 930 WP_032648334.1 LysR family transcriptional regulator -
DN066_RS12580 2569104..2569370 + 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
DN066_RS12585 2569358..2569843 + 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
DN066_RS12590 2569894..2570463 - 570 WP_032648331.1 hypothetical protein -
DN066_RS12595 2570479..2571444 - 966 WP_032648329.1 hypothetical protein -
DN066_RS12600 2571702..2572316 - 615 WP_065420578.1 NUDIX hydrolase -
DN066_RS12605 2572316..2573608 - 1293 WP_032648327.1 glycoside hydrolase -
DN066_RS12610 2573713..2574471 - 759 WP_015570520.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T106850 WP_003857133.1 NZ_CP030007:2569358-2569843 [Enterobacter hormaechei subsp. xiangfangensis]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T106850 NZ_CP030007:2569358-2569843 [Enterobacter hormaechei subsp. xiangfangensis]
GTGGGACGTGTAACAGCACCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGCGGAGAGGCCGTGCTTGA
CGAATGGCTAAAACAAAGAGGTCTGAAAAACCAGGCGCTCGGCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACGA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGCAAGCGACAGGTAATCTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATACTTGCCCGTCTGGCTGTGGATGTCTCGTTACGCGGAAACGGGTTGGGAGCCGATTT
ACTCCACGATGCGGTTTTACGCTGTTATCGTGTAGCAGAGAATATCGGGGTGCGGGCGATTATGGTTCATGCACTCACTG
AGGAAGCCAAAGCGTTTTATATCCACCATGGTTTCAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCCGGCTTCCC
CAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT106850 WP_003857131.1 NZ_CP030007:2569104-2569370 [Enterobacter hormaechei subsp. xiangfangensis]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT106850 NZ_CP030007:2569104-2569370 [Enterobacter hormaechei subsp. xiangfangensis]
ATGAAATCAGATGTTCAACTCAATCTCAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGCACGGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAGAATGTGATCCTCGATCGACGTGTATTCAATT
TTAACGATGAACAGTACGCAGAGTTCATTGACATGCTCGATGCCCCGGTCGCGGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCACAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References