Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 985023..985680 Replicon chromosome
Accession NZ_CP030007
Organism Enterobacter hormaechei subsp. xiangfangensis strain Pb204

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag DN066_RS04910 Protein ID WP_017382887.1
Coordinates 985270..985680 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag DN066_RS04905 Protein ID WP_003863437.1
Coordinates 985023..985289 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DN066_RS04885 980429..981862 - 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -
DN066_RS04890 981979..982710 - 732 WP_032649427.1 MurR/RpiR family transcriptional regulator -
DN066_RS04895 982977..983636 + 660 WP_003863433.1 hemolysin III family protein -
DN066_RS04900 983748..984728 - 981 WP_022649306.1 tRNA-modifying protein YgfZ -
DN066_RS04905 985023..985289 + 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
DN066_RS04910 985270..985680 + 411 WP_017382887.1 protein YgfX Toxin
DN066_RS04915 985682..986203 - 522 WP_032649423.1 flavodoxin FldB -
DN066_RS04920 986305..987201 + 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
DN066_RS04925 987230..987943 + 714 WP_015571792.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
DN066_RS04930 987949..989682 + 1734 WP_032649421.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T106840 WP_017382887.1 NZ_CP030007:985270-985680 [Enterobacter hormaechei subsp. xiangfangensis]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T106840 NZ_CP030007:985270-985680 [Enterobacter hormaechei subsp. xiangfangensis]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCCTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGGCTGGTGGCGGC
ACTGGTGTTATTGGTGCCGTGGCCGCTTAGCTATACCCCTCTGTGGTTGCTATTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGATGGGGACGCCGTGGATGCTTAATACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT106840 WP_003863437.1 NZ_CP030007:985023-985289 [Enterobacter hormaechei subsp. xiangfangensis]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT106840 NZ_CP030007:985023-985289 [Enterobacter hormaechei subsp. xiangfangensis]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References