Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3262..3787 Replicon plasmid pSA20141895.1
Accession NZ_CP030006
Organism Salmonella enterica subsp. enterica serovar Berta strain SA20141895

Toxin (Protein)


Gene name ccdB Uniprot ID I3VZQ7
Locus tag DOE61_RS24075 Protein ID WP_001159874.1
Coordinates 3482..3787 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID I3VZQ6
Locus tag DOE61_RS24070 Protein ID WP_000813642.1
Coordinates 3262..3480 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DOE61_RS24060 1340..2302 - 963 WP_000169858.1 hypothetical protein -
DOE61_RS24065 2307..2552 - 246 WP_000368362.1 hypothetical protein -
DOE61_RS24070 3262..3480 + 219 WP_000813642.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
DOE61_RS24075 3482..3787 + 306 WP_001159874.1 type II toxin-antitoxin system toxin CcdB Toxin
DOE61_RS24080 3789..4079 + 291 WP_001266178.1 hypothetical protein -
DOE61_RS24085 4442..4611 + 170 Protein_5 cytoplasmic protein -
DOE61_RS24090 4624..5406 + 783 WP_000082174.1 site-specific integrase -
DOE61_RS24095 5910..6605 + 696 WP_000389613.1 CPBP family intramembrane metalloprotease -
DOE61_RS24100 6912..7146 - 235 Protein_8 Rpn family recombination-promoting nuclease/putative transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..67730 67730


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-50)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 13091.77 Da        Isoelectric Point: 12.8043

>T106838 WP_001159874.1 NZ_CP030006:3482-3787 [Salmonella enterica subsp. enterica serovar Berta]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Download         Length: 306 bp

>T106838 NZ_CP030006:3482-3787 [Salmonella enterica subsp. enterica serovar Berta]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 9374.72 Da        Isoelectric Point: 12.6573

>AT106838 WP_000813642.1 NZ_CP030006:3262-3480 [Salmonella enterica subsp. enterica serovar Berta]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 219 bp

>AT106838 NZ_CP030006:3262-3480 [Salmonella enterica subsp. enterica serovar Berta]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A600Z065

Antitoxin

Source ID Structure
AlphaFold DB A0A600YYQ0

References