Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 71068..71594 Replicon plasmid pSA20064858.1
Accession NZ_CP030003
Organism Salmonella enterica subsp. enterica serovar Brandenburg strain SA20064858

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag DOE58_RS24425 Protein ID WP_000323025.1
Coordinates 71307..71594 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag DOE58_RS24420 Protein ID WP_000534858.1
Coordinates 71068..71307 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DOE58_RS24395 66850..68058 - 1209 WP_000121273.1 IncI1-type conjugal transfer protein TrbA -
DOE58_RS24400 68426..69766 + 1341 WP_001597880.1 ISNCY family transposase -
DOE58_RS24410 70203..70535 - 333 WP_001317460.1 FlxA-like family protein -
DOE58_RS24415 70738..71043 - 306 WP_001326990.1 hypothetical protein -
DOE58_RS24420 71068..71307 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
DOE58_RS24425 71307..71594 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
DOE58_RS24430 71666..71818 + 153 WP_001303307.1 Hok/Gef family protein -
DOE58_RS24435 71890..72141 - 252 WP_001291965.1 hypothetical protein -
DOE58_RS25030 73419..73556 - 138 WP_049290858.1 hypothetical protein -
DOE58_RS24455 73601..74827 - 1227 WP_052895285.1 transposase -
DOE58_RS24460 75469..75678 + 210 WP_052895278.1 HEAT repeat domain-containing protein -
DOE58_RS24465 75750..76412 - 663 WP_052895279.1 plasmid IncI1-type surface exclusion protein ExcA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..119613 119613


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-133)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-36)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 12322.73 Da        Isoelectric Point: 12.7777

>T106837 WP_000323025.1 NZ_CP030003:71307-71594 [Salmonella enterica subsp. enterica serovar Brandenburg]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKK

Download         Length: 288 bp

>T106837 NZ_CP030003:71307-71594 [Salmonella enterica subsp. enterica serovar Brandenburg]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 10271.94 Da        Isoelectric Point: 12.6975

>AT106837 WP_000534858.1 NZ_CP030003:71068-71307 [Salmonella enterica subsp. enterica serovar Brandenburg]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 240 bp

>AT106837 NZ_CP030003:71068-71307 [Salmonella enterica subsp. enterica serovar Brandenburg]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References