Detailed information of TA system TA106793

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsxAB/Xre(antitoxin)
• Location: 22541..23042
• Replicon: plasmid p51008369SK1_D
• Accession: NZ_CP029977
• Organism: Escherichia coli strain 51008369SK1

Toxin (Protein)

• Gene name: TsxA
• Uniprot ID: Q9F571
• Locus tag: DNQ41_RS26530
• Protein ID: WP_000702246.1
• Coordinates: 22782..23042 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: TsxB
• Uniprot ID: -
• Locus tag: DNQ41_RS26525
• Protein ID: WP_001132407.1
• Coordinates: 22541..22792 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DNQ41_RS26460	17777..18103	+	327	WP_000206697.1	hypothetical protein	-
DNQ41_RS26465	18234..18671	-	438	WP_000466318.1	type II toxin-antitoxin system HicB family antitoxin	-
DNQ41_RS26470	18696..18878	-	183	WP_000833470.1	type II toxin-antitoxin system HicA family toxin	-
DNQ41_RS26475	19412..19594	+	183	WP_111530679.1	hypothetical protein	-
DNQ41_RS26480	19701..19967	-	267	WP_000681608.1	type II toxin-antitoxin system HicB family antitoxin	-
DNQ41_RS26485	20387..20665	-	279	WP_000545937.1	hypothetical protein	-
DNQ41_RS26500	21215..21466	-	252	WP_001132407.1	transcriptional regulator	-
DNQ41_RS26505	21456..21716	-	261	WP_000702246.1	hypothetical protein	-
DNQ41_RS26510	21767..21991	-	225	WP_000814384.1	hypothetical protein	-
DNQ41_RS26525	22541..22792	-	252	WP_001132407.1	transcriptional regulator	Antitoxin
DNQ41_RS26530	22782..23042	-	261	WP_000702246.1	hypothetical protein	Toxin
DNQ41_RS26535	23093..23317	-	225	WP_000814384.1	hypothetical protein	-
DNQ41_RS26540	23415..23624	-	210	WP_000866037.1	hypothetical protein	-
DNQ41_RS26545	23665..23988	-	324	WP_000427402.1	hypothetical protein	-
DNQ41_RS26550	24569..24898	-	330	WP_000855118.1	hypothetical protein	-
DNQ41_RS26560	25496..26161	+	666	WP_000532148.1	P-loop NTPase	-
DNQ41_RS27980	26240..26524	+	285	WP_001162371.1	hypothetical protein	-
DNQ41_RS26570	26542..27138	-	597	WP_000125166.1	hypothetical protein	-
DNQ41_RS26575	27288..27449	-	162	WP_001366886.1	type I toxin-antitoxin system Hok family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	-	-	1..61284	61284

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (8-37)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 9891.42 Da
• Isoelectric Point: 10.0665

>T106793 WP_000702246.1 NZ_CP029977:c23042-22782 [Escherichia coli]
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFHEKAFDTIDFASDGLRENDKEIIFMMIQEMS
EGKNAK

Nucleotide

• Length: 261 bp

>T106793 NZ_CP029977:c23042-22782 [Escherichia coli]
ATGAAGATAAGAAAAGGTGACAGACAATATTATCTGAATAAAGAAGGTGATACATTTCATCTGGTGAAGCGAGTAAAAAC
TTTTTCTAAATCTGCGACTTTAGGAAAAACGAAAGCAACGGTGAAAACTGTTGCCGATCTTGTTTTTCATGAGAAGGCAT
TCGACACTATCGACTTTGCCAGCGACGGATTAAGAGAGAATGATAAAGAAATTATTTTTATGATGATTCAGGAAATGAGT
GAGGGAAAAAATGCCAAATGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9404.77 Da
• Isoelectric Point: 9.8120

>AT106793 WP_001132407.1 NZ_CP029977:c22792-22541 [Escherichia coli]
MPNENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN

Nucleotide

• Length: 252 bp

>AT106793 NZ_CP029977:c22792-22541 [Escherichia coli]
ATGCCAAATGAAAACACACCAGAAAACATTAAACGTCTGCGGCAAAAAATTGGCCTGACACAGAAAGAATGTGCCGAAAT
ATTTAGCATGAGTCCGCGTACCTGGCGTCGCAAAGAAGAACCTGTCGGAACTGCAAGCGGTACAGCACTTACACCAGTAG
AGTTTAAATTTCTTCTGCTTTTAGCTGGAGAACACCCTGATTATGTACTTTGTAAAAGGAATAAAAAGAATTCTGATTCT
GGAAGTAATTAA

Structures

Toxin

• AlphaFold DB: A0A3E1XBA7