106791

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsxAB/MqsA(antitoxin)
Location 29321..29786 Replicon plasmid p51008369SK1_C
Accession NZ_CP029976
Organism Escherichia coli strain 51008369SK1

Toxin (Protein)


Gene name TsxA Uniprot ID A0A5Y6UAV0
Locus tag DNQ41_RS26305 Protein ID WP_001230708.1
Coordinates 29535..29786 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name TsxB Uniprot ID M7CCF8
Locus tag DNQ41_RS26300 Protein ID WP_000801440.1
Coordinates 29321..29548 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DNQ41_RS27960 24691..24867 - 177 WP_000660496.1 hypothetical protein -
DNQ41_RS26260 25044..25259 - 216 WP_000760375.1 EexN family lipoprotein -
DNQ41_RS26265 25256..25549 - 294 WP_000134733.1 LuxR family transcriptional regulator -
DNQ41_RS26270 25626..26855 - 1230 WP_000539545.1 relaxase/mobilization nuclease domain-containing protein -
DNQ41_RS26275 26859..27362 - 504 WP_000781818.1 hypothetical protein -
DNQ41_RS26285 27725..27931 - 207 WP_000882678.1 type II toxin-antitoxin system HicB family antitoxin -
DNQ41_RS26290 28173..28538 - 366 WP_000854262.1 hypothetical protein -
DNQ41_RS26295 28630..28929 - 300 WP_000650313.1 hypothetical protein -
DNQ41_RS26300 29321..29548 - 228 WP_000801440.1 hypothetical protein Antitoxin
DNQ41_RS26305 29535..29786 - 252 WP_001230708.1 hypothetical protein Toxin
DNQ41_RS26310 29783..30325 - 543 WP_001083908.1 hypothetical protein -
DNQ41_RS26315 30430..30945 - 516 WP_001025396.1 J domain-containing protein -
DNQ41_RS26325 31584..31934 - 351 WP_000127483.1 hypothetical protein -
DNQ41_RS26330 31931..32266 - 336 WP_001147119.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..33826 33826


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-103)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9750.19 Da        Isoelectric Point: 9.8104

>T106791 WP_001230708.1 NZ_CP029976:c29786-29535 [Escherichia coli]
MRKNKGDVTYFLEKEGDNYRLTKRIKARTNVKIGNKTTKITLYDAVLNENELQHIDFTCAGLRKDDETPVKNLIKEFMLN
ETR

Download         Length: 252 bp

>T106791 NZ_CP029976:c29786-29535 [Escherichia coli]
ATGAGAAAAAATAAAGGTGATGTGACTTATTTTCTTGAAAAAGAAGGTGACAATTACAGGCTTACAAAAAGGATAAAAGC
CAGAACAAATGTTAAAATCGGGAACAAAACTACGAAAATCACATTGTATGATGCCGTACTGAATGAGAATGAATTACAAC
ATATTGATTTTACGTGTGCCGGATTAAGGAAAGACGATGAGACGCCAGTTAAGAATTTAATTAAGGAGTTTATGTTAAAT
GAAACCCGATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8659.98 Da        Isoelectric Point: 8.5105

>AT106791 WP_000801440.1 NZ_CP029976:c29548-29321 [Escherichia coli]
MKPDNTPENVKKLRLKAGLTQKECSHIYGVGLRTWQKKEEVNTQNSQSLSLVEFEFLLLLAGEHPEYVLCKRESK

Download         Length: 228 bp

>AT106791 NZ_CP029976:c29548-29321 [Escherichia coli]
ATGAAACCCGATAATACACCTGAAAATGTAAAAAAATTACGTTTAAAAGCAGGATTAACACAAAAGGAATGCAGTCATAT
TTATGGTGTTGGGCTAAGAACCTGGCAGAAAAAAGAGGAAGTTAATACTCAAAACAGTCAAAGTCTGTCACTGGTTGAGT
TTGAGTTTCTTTTGTTACTTGCAGGAGAACATCCTGAATACGTGCTCTGCAAAAGGGAGTCAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y6UAV0

Antitoxin

Source ID Structure
AlphaFold DB A0A5Y6U8W9

References