Detailed information of TA system TA106774

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 2882391..2883226
• Replicon: chromosome
• Accession: NZ_CP029973
• Organism: Escherichia coli strain 51008369SK1

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: DNQ41_RS14780
• Protein ID: WP_042046912.1
• Coordinates: 2882849..2883226 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: DNQ41_RS14775
• Protein ID: WP_135145692.1
• Coordinates: 2882391..2882759 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DNQ41_RS14745	2878393..2878866	+	474	WP_000855059.1	antirestriction protein	-
DNQ41_RS14750	2878882..2879334	+	453	WP_129445215.1	RadC family protein	-
DNQ41_RS14755	2879475..2881016	+	1542	WP_002431311.1	IS21-like element ISEc12 family transposase	-
DNQ41_RS14760	2881031..2881777	+	747	WP_001016257.1	IS21-like element ISEc12 family helper ATPase IstB	-
DNQ41_RS14765	2881864..2881944	+	81	Protein_2673	hypothetical protein	-
DNQ41_RS14770	2882007..2882228	+	222	WP_000692345.1	DUF987 domain-containing protein	-
DNQ41_RS14775	2882391..2882759	+	369	WP_135145692.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
DNQ41_RS14780	2882849..2883226	+	378	WP_042046912.1	TA system toxin CbtA family protein	Toxin
DNQ41_RS14785	2883223..2883426	+	204	WP_000761705.1	hypothetical protein	-
DNQ41_RS14790	2883439..2883552	+	114	WP_032140621.1	DUF957 domain-containing protein	-
DNQ41_RS27875	2884350..2884739	+	390	WP_077875581.1	transposase	-
DNQ41_RS14805	2885193..2885375	+	183	WP_024198358.1	ethanolamine utilization protein	-
DNQ41_RS14810	2885476..2885805	-	330	WP_000450409.1	DUF496 family protein	-
DNQ41_RS14815	2885977..2887035	-	1059	WP_001200895.1	FUSC family protein	-
DNQ41_RS14820	2887233..2887706	-	474	WP_001105407.1	DNA gyrase inhibitor SbmC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14020.96 Da
• Isoelectric Point: 7.8276

>T106774 WP_042046912.1 NZ_CP029973:2882849-2883226 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Nucleotide

• Length: 378 bp

>T106774 NZ_CP029973:2882849-2883226 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13545.30 Da
• Isoelectric Point: 6.4764

>AT106774 WP_135145692.1 NZ_CP029973:2882391-2882759 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPHHQHTVTLYAKGLTCEADTLGSCGYAYLAVYPTPETKK

Nucleotide

• Length: 369 bp

>AT106774 NZ_CP029973:2882391-2882759 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCACCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGCGAAGCCGATACCCTTGGCAGTTG
TGGTTACGCTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA