Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 80952..81553 Replicon plasmid pK91
Accession NZ_CP029963
Organism Salmonella enterica subsp. enterica serovar Typhi strain 343078_228140

Toxin (Protein)


Gene name doc Uniprot ID A0A5U0JPI4
Locus tag SM228140_RS24880 Protein ID WP_024166788.1
Coordinates 81173..81553 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag SM228140_RS24875 Protein ID WP_001190712.1
Coordinates 80952..81173 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SM228140_RS24830 76583..76996 - 414 Protein_73 Tn3 family transposase -
SM228140_RS24835 77175..78374 - 1200 WP_000948429.1 IS91 family transposase -
SM228140_RS24840 78384..78572 - 189 WP_000957857.1 hypothetical protein -
SM228140_RS24845 78680..79345 - 666 Protein_76 IS5 family transposase -
SM228140_RS24850 79304..79501 + 198 WP_048659784.1 DUF4752 family protein -
SM228140_RS24855 79549..79788 + 240 Protein_78 hypothetical protein -
SM228140_RS24860 79924..80124 + 201 WP_001408980.1 hypothetical protein -
SM228140_RS24865 80127..80375 + 249 WP_001286530.1 DNA polymerase III subunit theta -
SM228140_RS24870 80487..80879 + 393 WP_000506718.1 hypothetical protein -
SM228140_RS24875 80952..81173 + 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SM228140_RS24880 81173..81553 + 381 WP_024166788.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
SM228140_RS24885 81637..82437 - 801 WP_001743161.1 hypothetical protein -
SM228140_RS24890 82451..82945 - 495 WP_048659776.1 dUTP diphosphatase -
SM228140_RS24895 82938..83429 - 492 WP_004010538.1 hypothetical protein -
SM228140_RS24900 83426..83770 - 345 WP_004010537.1 hypothetical protein -
SM228140_RS24905 83843..84871 - 1029 WP_048659775.1 tyrosine-type recombinase/integrase -
SM228140_RS24910 85269..86306 + 1038 WP_048659773.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..93445 93445


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-69)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 16296.13 Da        Isoelectric Point: 12.9004

>T106755 WP_024166788.1 NZ_CP029963:81173-81553 [Salmonella enterica subsp. enterica serovar Typhi]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 381 bp

>T106755 NZ_CP029963:81173-81553 [Salmonella enterica subsp. enterica serovar Typhi]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 9502.90 Da        Isoelectric Point: 12.6633

>AT106755 WP_001190712.1 NZ_CP029963:80952-81173 [Salmonella enterica subsp. enterica serovar Typhi]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 222 bp

>AT106755 NZ_CP029963:80952-81173 [Salmonella enterica subsp. enterica serovar Typhi]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5U0JPI4

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References