Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc-Phd |
| Location | 22519..23120 | Replicon | plasmid pK91 |
| Accession | NZ_CP029874 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhi strain 343077_211171 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | A0A5U0JPI4 |
| Locus tag | SM211171_RS24555 | Protein ID | WP_024166788.1 |
| Coordinates | 22519..22899 (-) | Length | 127 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | U9YQH9 |
| Locus tag | SM211171_RS24560 | Protein ID | WP_001190712.1 |
| Coordinates | 22899..23120 (-) | Length | 74 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SM211171_RS24525 | 17766..18803 | - | 1038 | WP_048659773.1 | hypothetical protein | - |
| SM211171_RS24530 | 19201..20229 | + | 1029 | WP_048659775.1 | tyrosine-type recombinase/integrase | - |
| SM211171_RS24535 | 20302..20646 | + | 345 | WP_004010537.1 | hypothetical protein | - |
| SM211171_RS24540 | 20643..21134 | + | 492 | WP_004010538.1 | hypothetical protein | - |
| SM211171_RS24545 | 21127..21621 | + | 495 | WP_048659776.1 | dUTP diphosphatase | - |
| SM211171_RS24550 | 21635..22435 | + | 801 | WP_001743161.1 | hypothetical protein | - |
| SM211171_RS24555 | 22519..22899 | - | 381 | WP_024166788.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| SM211171_RS24560 | 22899..23120 | - | 222 | WP_001190712.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| SM211171_RS24565 | 23193..23585 | - | 393 | WP_000506718.1 | hypothetical protein | - |
| SM211171_RS24570 | 23697..23945 | - | 249 | WP_001286530.1 | DNA polymerase III subunit theta | - |
| SM211171_RS24575 | 23948..24148 | - | 201 | WP_001408980.1 | hypothetical protein | - |
| SM211171_RS24580 | 24284..24523 | - | 240 | Protein_28 | hypothetical protein | - |
| SM211171_RS24585 | 24571..24768 | - | 198 | WP_048659784.1 | DUF4752 family protein | - |
| SM211171_RS24590 | 24727..25392 | + | 666 | Protein_30 | IS5 family transposase | - |
| SM211171_RS24595 | 25500..25688 | + | 189 | WP_000957857.1 | hypothetical protein | - |
| SM211171_RS24600 | 25698..26897 | + | 1200 | WP_000948429.1 | IS91 family transposase | - |
| SM211171_RS24605 | 27076..27489 | + | 414 | Protein_33 | Tn3 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..91892 | 91892 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 127 a.a. Molecular weight: 18709.44 Da Isoelectric Point: 5.5500
>T106753 WP_024166788.1 NZ_CP029874:c22899-22519 [Salmonella enterica subsp. enterica serovar Typhi]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
Download Length: 381 bp
>T106753 NZ_CP029874:c22899-22519 [Salmonella enterica subsp. enterica serovar Typhi]
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Antitoxin
Download Length: 74 a.a. Molecular weight: 10909.08 Da Isoelectric Point: 5.5500
>AT106753 WP_001190712.1 NZ_CP029874:c23120-22899 [Salmonella enterica subsp. enterica serovar Typhi]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
Download Length: 222 bp
>AT106753 NZ_CP029874:c23120-22899 [Salmonella enterica subsp. enterica serovar Typhi]
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Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5U0JPI4 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829CJB6 |