Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 61625..62226 Replicon plasmid pK91
Accession NZ_CP029871
Organism Salmonella enterica subsp. enterica serovar Typhi strain 343077_214135

Toxin (Protein)


Gene name doc Uniprot ID A0A5U0JPI4
Locus tag SM214135_RS00340 Protein ID WP_024166788.1
Coordinates 61846..62226 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag SM214135_RS00335 Protein ID WP_001190712.1
Coordinates 61625..61846 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SM214135_RS00290 57256..57669 - 414 Protein_54 Tn3 family transposase -
SM214135_RS00295 57848..59047 - 1200 WP_000948429.1 IS91 family transposase -
SM214135_RS00300 59057..59245 - 189 WP_000957857.1 hypothetical protein -
SM214135_RS00305 59353..60018 - 666 Protein_57 IS5 family transposase -
SM214135_RS00310 59977..60174 + 198 WP_048659784.1 DUF4752 family protein -
SM214135_RS00315 60222..60461 + 240 Protein_59 hypothetical protein -
SM214135_RS00320 60597..60797 + 201 WP_001408980.1 hypothetical protein -
SM214135_RS00325 60800..61048 + 249 WP_001286530.1 DNA polymerase III subunit theta -
SM214135_RS00330 61160..61552 + 393 WP_000506718.1 hypothetical protein -
SM214135_RS00335 61625..61846 + 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SM214135_RS00340 61846..62226 + 381 WP_024166788.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
SM214135_RS00345 62310..63110 - 801 WP_001743161.1 hypothetical protein -
SM214135_RS00350 63124..63618 - 495 WP_048659776.1 dUTP diphosphatase -
SM214135_RS00355 63611..64102 - 492 WP_004010538.1 hypothetical protein -
SM214135_RS00360 64099..64443 - 345 WP_004010537.1 hypothetical protein -
SM214135_RS00365 64516..65544 - 1029 WP_048659775.1 tyrosine-type recombinase/integrase -
SM214135_RS00370 65942..66979 + 1038 WP_048659773.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..91848 91848


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 16296.13 Da        Isoelectric Point: 12.9004

>T106752 WP_024166788.1 NZ_CP029871:61846-62226 [Salmonella enterica subsp. enterica serovar Typhi]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 381 bp

>T106752 NZ_CP029871:61846-62226 [Salmonella enterica subsp. enterica serovar Typhi]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 9502.90 Da        Isoelectric Point: 12.6633

>AT106752 WP_001190712.1 NZ_CP029871:61625-61846 [Salmonella enterica subsp. enterica serovar Typhi]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 222 bp

>AT106752 NZ_CP029871:61625-61846 [Salmonella enterica subsp. enterica serovar Typhi]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5U0JPI4

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References