Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 61668..62269 Replicon plasmid pK91
Accession NZ_CP029869
Organism Salmonella enterica subsp. enterica serovar Typhi strain 343077_215174

Toxin (Protein)


Gene name doc Uniprot ID A0A5U0JPI4
Locus tag SM215174_RS24795 Protein ID WP_024166788.1
Coordinates 61889..62269 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag SM215174_RS24790 Protein ID WP_001190712.1
Coordinates 61668..61889 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SM215174_RS24745 57299..57712 - 414 Protein_54 Tn3 family transposase -
SM215174_RS24750 57891..59090 - 1200 WP_000948429.1 IS91 family transposase -
SM215174_RS24755 59100..59288 - 189 WP_000957857.1 hypothetical protein -
SM215174_RS24760 59396..60061 - 666 Protein_57 IS5 family transposase -
SM215174_RS24765 60020..60217 + 198 WP_048659784.1 DUF4752 family protein -
SM215174_RS24770 60265..60504 + 240 Protein_59 hypothetical protein -
SM215174_RS24775 60640..60840 + 201 WP_001408980.1 hypothetical protein -
SM215174_RS24780 60843..61091 + 249 WP_001286530.1 DNA polymerase III subunit theta -
SM215174_RS24785 61203..61595 + 393 WP_000506718.1 hypothetical protein -
SM215174_RS24790 61668..61889 + 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SM215174_RS24795 61889..62269 + 381 WP_024166788.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
SM215174_RS24800 62353..63153 - 801 WP_001743161.1 hypothetical protein -
SM215174_RS24805 63167..63661 - 495 WP_048659776.1 dUTP diphosphatase -
SM215174_RS24810 63654..64145 - 492 WP_004010538.1 hypothetical protein -
SM215174_RS24815 64142..64486 - 345 WP_004010537.1 hypothetical protein -
SM215174_RS24820 64559..65587 - 1029 WP_048659775.1 tyrosine-type recombinase/integrase -
SM215174_RS24825 65985..67022 + 1038 WP_048659773.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..91891 91891


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 16296.13 Da        Isoelectric Point: 12.9004

>T106751 WP_024166788.1 NZ_CP029869:61889-62269 [Salmonella enterica subsp. enterica serovar Typhi]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 381 bp

>T106751 NZ_CP029869:61889-62269 [Salmonella enterica subsp. enterica serovar Typhi]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 9502.90 Da        Isoelectric Point: 12.6633

>AT106751 WP_001190712.1 NZ_CP029869:61668-61889 [Salmonella enterica subsp. enterica serovar Typhi]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 222 bp

>AT106751 NZ_CP029869:61668-61889 [Salmonella enterica subsp. enterica serovar Typhi]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5U0JPI4

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References