Detailed information of TA system TA106746

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 51248..51773
• Replicon: plasmid p10ST07093B
• Accession: NZ_CP029838
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain 10ST07093

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: I3W3D5
• Locus tag: DM286_RS00960
• Protein ID: WP_001159863.1
• Coordinates: 51248..51553 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: M7S5D0
• Locus tag: DM286_RS00965
• Protein ID: WP_000813641.1
• Coordinates: 51555..51773 (-)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DM286_RS00915	46618..47178	-	561	WP_000900095.1	inverse autotransporter beta domain-containing protein	-
DM286_RS00925	47907..48392	-	486	WP_000905606.1	membrane protein	-
DM286_RS00930	48386..48895	-	510	WP_001541544.1	CaiF/GrlA family transcriptional regulator	-
DM286_RS00940	48899..49612	-	714	Protein_62	EAL domain-containing protein	-
DM286_RS00945	49621..50403	-	783	WP_000082169.1	site-specific integrase	-
DM286_RS00950	50438..50959	-	522	WP_000198608.1	hypothetical protein	-
DM286_RS00955	50956..51246	-	291	WP_001266176.1	hypothetical protein	-
DM286_RS00960	51248..51553	-	306	WP_001159863.1	type II toxin-antitoxin system toxin CcdB	Toxin
DM286_RS00965	51555..51773	-	219	WP_000813641.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
DM286_RS00970	52449..52970	+	522	WP_010999942.1	hypothetical protein	-
DM286_RS00980	53454..53750	+	297	WP_001687482.1	hypothetical protein	-
DM286_RS00985	54244..55233	+	990	WP_001527061.1	RepB family plasmid replication initiator protein	-
DM286_RS00990	55492..55936	-	445	Protein_71	site-specific integrase	-
DM286_RS00995	56105..56486	-	382	Protein_72	YgiW/YdeI family stress tolerance OB fold protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..93798	93798

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-146)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (29-90)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 15030.03 Da
• Isoelectric Point: 5.5500

>T106746 WP_001159863.1 NZ_CP029838:c51553-51248 [Salmonella enterica subsp. enterica serovar Typhimurium]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 306 bp

>T106746 NZ_CP029838:c51553-51248 [Salmonella enterica subsp. enterica serovar Typhimurium]
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Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 10761.91 Da
• Isoelectric Point: 5.5500

>AT106746 WP_000813641.1 NZ_CP029838:c51773-51555 [Salmonella enterica subsp. enterica serovar Typhimurium]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 219 bp

>AT106746 NZ_CP029838:c51773-51555 [Salmonella enterica subsp. enterica serovar Typhimurium]
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Structures

Toxin

• AlphaFold DB: I3W3D5

Antitoxin

• AlphaFold DB: A0A656ICA6