Detailed information of TA system TA106745

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 68156..68715
• Replicon: plasmid p10ST07093A
• Accession: NZ_CP029837
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain 10ST07093

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: DM286_RS00420
• Protein ID: WP_000421275.1
• Coordinates: 68440..68715 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A418GAX7
• Locus tag: DM286_RS00415
• Protein ID: WP_024186313.1
• Coordinates: 68156..68440 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DM286_RS00365	63634..64167	-	534	WP_001306770.1	transcription termination factor NusG	-
DM286_RS00375	64609..64896	-	288	WP_000074849.1	conjugal transfer protein TraA	-
DM286_RS00380	64814..65077	-	264	WP_001324596.1	ash family protein	-
DM286_RS00395	66050..67081	+	1032	WP_000907872.1	hypothetical protein	-
DM286_RS00415	68156..68440	+	285	WP_024186313.1	ribbon-helix-helix protein, CopG family	Antitoxin
DM286_RS00420	68440..68715	+	276	WP_000421275.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DM286_RS00425	68821..69102	+	282	WP_001105066.1	hypothetical protein	-
DM286_RS00435	69293..69559	-	267	WP_000627833.1	hypothetical protein	-
DM286_RS00440	69628..70053	-	426	WP_001389390.1	hypothetical protein	-
DM286_RS00445	70109..70711	-	603	WP_000517689.1	hypothetical protein	-
DM286_RS00455	71065..72411	+	1347	WP_001132021.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..93657	93657

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 11810.03 Da
• Isoelectric Point: 12.7590

>T106745 WP_000421275.1 NZ_CP029837:68440-68715 [Salmonella enterica subsp. enterica serovar Typhimurium]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKK

Nucleotide

• Length: 276 bp

>T106745 NZ_CP029837:68440-68715 [Salmonella enterica subsp. enterica serovar Typhimurium]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 12194.55 Da
• Isoelectric Point: 12.7731

>AT106745 WP_024186313.1 NZ_CP029837:68156-68440 [Salmonella enterica subsp. enterica serovar Typhimurium]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKK

Nucleotide

• Length: 285 bp

>AT106745 NZ_CP029837:68156-68440 [Salmonella enterica subsp. enterica serovar Typhimurium]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Structures

Antitoxin

• AlphaFold DB: A0A418GAX7