Detailed information of TA system TA106742

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 3173301..3173940
• Replicon: chromosome
• Accession: NZ_CP029825
• Organism: Burkholderia sp. JP2-270

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: DM992_RS32500
• Protein ID: WP_204356150.1
• Coordinates: 3173524..3173940 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A4V8GAU9
• Locus tag: DM992_RS32495
• Protein ID: WP_014899176.1
• Coordinates: 3173301..3173537 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DM992_RS32470	3168474..3169517	+	1044	WP_111020186.1	ferredoxin--NADP reductase	-
DM992_RS32475	3169556..3171136	+	1581	WP_204356188.1	FadD3 family acyl-CoA ligase	-
DM992_RS42450	3171283..3171429	+	147	Protein_2864	IS256 family transposase	-
DM992_RS32490	3172207..3172884	+	678	WP_111020520.1	hypothetical protein	-
DM992_RS32495	3173301..3173537	+	237	WP_014899176.1	DNA-binding protein	Antitoxin
DM992_RS32500	3173524..3173940	+	417	WP_204356150.1	PIN domain-containing protein	Toxin
DM992_RS32505	3174343..3175239	+	897	WP_111020190.1	VOC family protein	-
DM992_RS32510	3175249..3176151	+	903	WP_111020191.1	CoA transferase subunit A	-
DM992_RS32515	3176162..3176959	+	798	WP_111020192.1	ketoacid CoA transferase	-
DM992_RS32520	3176968..3177888	+	921	WP_111020193.1	enoyl-CoA hydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-130)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15398.65 Da
• Isoelectric Point: 6.8816

>T106742 WP_204356150.1 NZ_CP029825:3173524-3173940 [Burkholderia sp. JP2-270]
VFLIDTNVISEIRKGKRTNRGVRAFFRQAEADASPLYLSVVTVAELRRGVDLIRHRGDHPQASALEAWMATVLSGYAPNI
LPVDIEISQMWGHLRVPDPTHELDKLIAATALINDLTVVTRNVDDFARTGVRLLNPFD

Nucleotide

• Length: 417 bp

>T106742 NZ_CP029825:3173524-3173940 [Burkholderia sp. JP2-270]
GTGTTTTTGATTGATACGAACGTCATCAGCGAAATCAGGAAGGGCAAGCGAACCAACCGCGGCGTGCGGGCGTTCTTCAG
GCAGGCCGAGGCCGACGCGAGCCCGCTTTACCTGTCCGTCGTGACGGTGGCGGAACTTCGGCGCGGCGTCGACCTGATCC
GTCATCGCGGCGATCACCCTCAGGCGTCGGCGCTCGAAGCATGGATGGCGACGGTCCTGTCCGGCTATGCGCCGAACATC
CTGCCGGTCGATATCGAGATCAGCCAGATGTGGGGGCATTTGCGCGTGCCCGATCCGACGCACGAACTCGACAAACTGAT
CGCGGCCACCGCGCTGATCAACGATCTCACGGTCGTCACGCGTAATGTCGACGATTTCGCTCGCACCGGCGTCCGGCTGC
TGAACCCGTTCGACTAG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8668.70 Da
• Isoelectric Point: 5.0628

>AT106742 WP_014899176.1 NZ_CP029825:3173301-3173537 [Burkholderia sp. JP2-270]
MANLLVRNVDDSIVQSLREQAAANGRSAEAEHRAILADALGRPKRRTFAQVLMSMPDVGEDADFQRVQDSGEVRRVFD

Nucleotide

• Length: 237 bp

>AT106742 NZ_CP029825:3173301-3173537 [Burkholderia sp. JP2-270]
ATGGCAAATCTTCTGGTGCGTAACGTGGATGACAGTATCGTTCAGAGCCTGCGCGAGCAGGCTGCGGCAAATGGCAGGAG
TGCCGAGGCCGAACATCGGGCCATTCTGGCCGATGCGCTCGGCCGGCCGAAGCGAAGGACATTTGCGCAAGTGCTGATGA
GCATGCCCGACGTTGGCGAAGACGCGGATTTCCAACGTGTTCAGGATTCCGGCGAGGTCAGGCGTGTTTTTGATTGA

Structures

Antitoxin

• AlphaFold DB: A0A4V8GAU9