Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2882960..2884811 Replicon chromosome
Accession NZ_CP029825
Organism Burkholderia sp. JP2-270

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag DM992_RS31190 Protein ID WP_111019981.1
Coordinates 2882960..2883856 (+) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag DM992_RS31195 Protein ID WP_111019982.1
Coordinates 2883957..2884811 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DM992_RS31160 2878338..2879417 - 1080 WP_111019978.1 porin -
DM992_RS31165 2879865..2880182 + 318 WP_027789384.1 non-heme iron oxygenase ferredoxin subunit -
DM992_RS31170 2880184..2880495 + 312 WP_034180372.1 hypothetical protein -
DM992_RS31175 2880551..2881621 + 1071 WP_111019979.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
DM992_RS31180 2881614..2882384 + 771 WP_111019980.1 SDR family oxidoreductase -
DM992_RS31185 2882414..2882941 + 528 WP_034180369.1 cupin domain-containing protein -
DM992_RS31190 2882960..2883856 + 897 WP_111019981.1 alpha/beta fold hydrolase Toxin
DM992_RS31195 2883957..2884811 + 855 WP_111019982.1 IclR family transcriptional regulator Antitoxin
DM992_RS31200 2884808..2885605 + 798 WP_111019983.1 SDR family oxidoreductase -
DM992_RS31205 2885598..2887265 + 1668 WP_111019984.1 thiamine pyrophosphate-binding protein -
DM992_RS31210 2887258..2888073 + 816 WP_111019985.1 aspartate dehydrogenase -
DM992_RS31215 2888163..2889653 + 1491 WP_111019986.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-279)

Antitoxin

Transcription regulator IclR, C-terminal

(142-265)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30680.97 Da        Isoelectric Point: 8.0625

>T106741 WP_111019981.1 NZ_CP029825:2882960-2883856 [Burkholderia sp. JP2-270]
MSVIDKRERDRTAAFAALLGRFPEQRCAAGAAGTIGYREAGAQHAGRALPVVLLHGIGSGAASWVRQLDALGASRRVLAW
DAPGYGASTPVHGASPAAADYAASLNAWLEALGIERCVLVGHSLGAIVAGGLARVMPARIAGLLLVSPAGGYGSAPAETR
ESRRDARLAMLAELGPAGLAEQRSGNMLSGFASEDARAWVRWNMARIMPAGYAQATHLLANADLATDLAGFRGRTAVAVG
ANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAVYSALIDTFCRQCDTQWGLV

Download         Length: 897 bp

>T106741 NZ_CP029825:2882960-2883856 [Burkholderia sp. JP2-270]
ATGAGTGTCATCGACAAACGTGAACGCGACCGCACCGCGGCGTTCGCCGCGCTGCTCGGGCGGTTTCCCGAGCAGCGTTG
TGCGGCCGGCGCGGCGGGTACGATCGGTTATCGCGAGGCCGGCGCGCAGCATGCGGGCCGCGCGCTGCCCGTCGTGCTGC
TGCACGGGATCGGCTCGGGCGCCGCATCGTGGGTGCGCCAGCTCGACGCGCTCGGCGCATCGCGGCGCGTGCTCGCGTGG
GATGCGCCCGGTTATGGCGCGTCGACGCCCGTGCACGGCGCGTCGCCGGCCGCCGCCGATTACGCGGCGTCGCTGAACGC
GTGGCTCGAGGCACTCGGCATCGAACGCTGCGTGCTGGTCGGGCATTCGCTCGGCGCGATCGTCGCGGGCGGTCTTGCCC
GCGTGATGCCCGCGCGGATCGCCGGCCTGCTGCTGGTGTCGCCTGCCGGCGGCTATGGCAGCGCGCCCGCCGAAACGCGC
GAATCGCGCCGCGACGCGCGGCTCGCGATGCTCGCGGAACTCGGCCCGGCCGGGCTCGCCGAGCAGCGCAGCGGCAACAT
GCTGTCCGGTTTCGCGAGCGAGGATGCGCGTGCGTGGGTGCGCTGGAACATGGCACGCATCATGCCGGCAGGCTACGCGC
AGGCCACGCATCTGCTTGCGAACGCCGATCTTGCGACCGATCTCGCCGGTTTTCGCGGCCGCACGGCCGTGGCCGTCGGC
GCGAACGACGCGATCACGCCGCCCGCCGCATGCGAGCGGATCGCCGCGGCCGCGCACGTCGGGCTGCAGGTGATTCCGCA
AGCCGGTCATGCCGGGTACGTGGAAGCGCCGGCCGTTTATTCCGCACTGATCGACACGTTCTGCCGTCAGTGCGATACGC
AGTGGGGGCTGGTATGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31278.71 Da        Isoelectric Point: 6.1491

>AT106741 WP_111019982.1 NZ_CP029825:2883957-2884811 [Burkholderia sp. JP2-270]
MSDPLQQEPENGKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYKL
GIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQSPVFSSIRVNVGTRLPAYATTHGHV
LMGDLSLKELRSLYPEGTLNRMTSATPETVDALYEAIREDALRGYGVSNSSFERGISVVTAPVRNETQKIVACITVTVPR
PEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFMNALGLR

Download         Length: 855 bp

>AT106741 NZ_CP029825:2883957-2884811 [Burkholderia sp. JP2-270]
ATGAGCGACCCGCTGCAACAAGAACCCGAAAACGGGAAGGCCGAGGCCAGCTACGTGGTGCCGGGCCTCGAACGCGGGCT
GCGGATTCTCGCCGAATTCTCGCCGCGCGAGCCAGTGCTCGGCGCGCCCGAATTGTCGAAGCGGCTCGGCATTCCGCGCA
CGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTCGGCTTCCTCGAGCGTGCGGACAAGGATCGCAACTACAAGCTC
GGCATCGCCGTGCTGCGGCTCGGCTTCGAATACCTGAGCTCGCTGGAGCTGACCGATCTCGGCCTGCCGGTGATCGAGAG
CCTGCGCGACGCGACCGGCTTCACGACGCACATCGTGATCCGCGACGGCCGCGACGTCGTGTTCGTCGCGAAGGCGCAGA
GCCAGTCGCCGGTGTTCAGCTCGATTCGCGTGAACGTCGGAACCCGCTTGCCCGCGTATGCGACGACGCACGGCCACGTG
CTGATGGGCGACCTGTCGCTGAAGGAGCTGCGCTCGCTGTACCCGGAAGGCACGCTGAACCGGATGACGAGCGCGACGCC
GGAGACGGTCGATGCGTTGTACGAAGCGATCCGCGAGGATGCGCTGCGCGGCTACGGCGTCAGCAATTCGTCGTTCGAGC
GCGGCATCTCGGTGGTCACGGCACCCGTGCGCAACGAGACGCAGAAGATCGTCGCGTGCATCACGGTGACGGTGCCGCGG
CCGGAGATCGACGCGGCGCTGATCGCGGACGGTCTGATCGACAAGGTGCAGCGCGCGGCGGCGGAACTGTCGCGGCGGCT
CAATTACCGCTCGGATGACGAGCACACGTTTATGAATGCTTTAGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References