Detailed information of TA system TA106739

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbE-relB/ParE-YafN
• Location: 1604951..1605470
• Replicon: chromosome
• Accession: NZ_CP029825
• Organism: Burkholderia sp. JP2-270

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: -
• Locus tag: DM992_RS25105
• Protein ID: WP_111019096.1
• Coordinates: 1604951..1605232 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: DM992_RS25110
• Protein ID: WP_111019097.1
• Coordinates: 1605222..1605470 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DM992_RS25085	1600621..1601319	-	699	WP_111019093.1	MgtC/SapB family protein	-
DM992_RS25090	1601435..1602544	+	1110	WP_111019094.1	AGE family epimerase/isomerase	-
DM992_RS25095	1602517..1604145	-	1629	WP_111019095.1	Tar ligand binding domain-containing protein	-
DM992_RS25100	1604451..1604894	+	444	WP_034181638.1	PaaI family thioesterase	-
DM992_RS25105	1604951..1605232	-	282	WP_111019096.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DM992_RS25110	1605222..1605470	-	249	WP_111019097.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
DM992_RS25115	1605589..1606641	-	1053	WP_111019098.1	CoA transferase	-
DM992_RS25125	1606870..1608063	-	1194	WP_111020387.1	2-methylaconitate cis-trans isomerase PrpF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10936.87 Da
• Isoelectric Point: 10.8640

>T106739 WP_111019096.1 NZ_CP029825:c1605232-1604951 [Burkholderia sp. JP2-270]
MTFELAFLEAALKEWKKLDRTVRDQFKARLAERLENPRIPSAKLHGHPDRYKIKLRSVGYRLVYEVRDAQIVVLVVAVGR
RERDAVYLAAMKR

Nucleotide

• Length: 282 bp

>T106739 NZ_CP029825:c1605232-1604951 [Burkholderia sp. JP2-270]
ATGACCTTTGAACTCGCCTTTCTCGAAGCTGCGTTGAAGGAGTGGAAGAAGCTCGATCGCACCGTTCGCGATCAGTTCAA
GGCCAGGCTCGCCGAACGGCTCGAGAATCCTCGCATTCCGTCGGCGAAGCTGCACGGTCATCCGGACCGCTACAAGATCA
AGCTGCGCAGCGTCGGCTATCGCCTCGTGTACGAAGTGCGCGATGCGCAGATCGTCGTACTGGTTGTCGCGGTGGGGCGT
CGCGAGCGCGATGCGGTCTATCTCGCCGCAATGAAACGCTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8965.29 Da
• Isoelectric Point: 5.0636

>AT106739 WP_111019097.1 NZ_CP029825:c1605470-1605222 [Burkholderia sp. JP2-270]
MPHTILASVTASVSELKRNPMGTVAAGEGFPVAILNHNEPAFYCIPAKTWEAMVERLEDIEDNALADSRTKEKAVKVKLN
DL

Nucleotide

• Length: 249 bp

>AT106739 NZ_CP029825:c1605470-1605222 [Burkholderia sp. JP2-270]
ATGCCCCACACCATCCTGGCCAGCGTGACGGCGAGCGTCTCGGAGCTGAAGCGGAACCCGATGGGAACCGTGGCGGCGGG
AGAGGGCTTCCCGGTCGCGATCCTGAATCACAACGAACCCGCGTTCTATTGCATCCCGGCGAAGACATGGGAGGCGATGG
TCGAGCGTCTCGAAGATATCGAAGACAACGCGCTGGCCGACTCGCGCACCAAGGAGAAAGCCGTCAAGGTCAAGCTGAAT
GACCTTTGA