Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 1010851..1012069 Replicon chromosome
Accession NZ_CP029825
Organism Burkholderia sp. JP2-270

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag DM992_RS22425 Protein ID WP_111018694.1
Coordinates 1011488..1012069 (+) Length 194 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag DM992_RS22420 Protein ID WP_111018693.1
Coordinates 1010851..1011408 (+) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DM992_RS22395 1005870..1006460 + 591 WP_111018688.1 cysteine hydrolase -
DM992_RS22400 1006705..1007436 - 732 WP_111018689.1 ribonuclease T2 -
DM992_RS22405 1007689..1008267 - 579 WP_111018690.1 hypothetical protein -
DM992_RS22410 1008362..1009765 - 1404 WP_111018691.1 DUF308 domain-containing protein -
DM992_RS22415 1010130..1010768 + 639 WP_111018692.1 hypothetical protein -
DM992_RS22420 1010851..1011408 + 558 WP_111018693.1 helix-turn-helix domain-containing protein Antitoxin
DM992_RS22425 1011488..1012069 + 582 WP_111018694.1 HD domain-containing protein Toxin
DM992_RS22430 1012358..1013551 + 1194 WP_111018695.1 efflux RND transporter periplasmic adaptor subunit -
DM992_RS22435 1013554..1015596 + 2043 WP_111018696.1 MacB family efflux pump subunit -
DM992_RS22440 1015610..1016983 + 1374 WP_111020351.1 efflux transporter outer membrane subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(6-155)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-64)


Sequences

Toxin        


Download         Length: 194 a.a.        Molecular weight: 21335.91 Da        Isoelectric Point: 4.9532

>T106738 WP_111018694.1 NZ_CP029825:1011488-1012069 [Burkholderia sp. JP2-270]
MNPDTIHARLDFLREAERLKDVLRSGHTSAGRAESTAEHSWRLCLMALVFADALPGIDTLKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSAHERDDLLTLTASLDRTLRDEIVALWDEYEAAASPEARAAKALDKLETILQHNQGSNPPDFDYAFNLGY
GRRYTDAAPLFSAIRDIVDADTQRRIDAAGQRA

Download         Length: 582 bp

>T106738 NZ_CP029825:1011488-1012069 [Burkholderia sp. JP2-270]
ATGAACCCCGACACGATCCACGCACGCCTCGATTTCCTGCGCGAAGCCGAACGCCTGAAGGACGTGCTGCGCAGCGGCCA
CACGTCGGCCGGGCGCGCGGAAAGCACGGCCGAGCATAGCTGGCGGCTGTGCCTGATGGCGCTCGTGTTCGCCGACGCGC
TGCCCGGCATCGATACGCTGAAGCTGCTGAAACTGTGCGTCGTCCACGATCTCGGCGAAGCGCTGCACGGCGACATCCCT
GCGATCGAGCAGGCCGCGCACCCGGACAAAAGCGCGCACGAACGCGACGACCTGCTCACCCTGACAGCGTCGCTCGATCG
CACGCTGCGCGACGAGATCGTCGCGCTGTGGGATGAATACGAGGCGGCCGCGTCGCCGGAAGCACGCGCGGCGAAGGCGC
TCGACAAGCTCGAGACGATCCTGCAGCACAACCAGGGCAGCAATCCGCCCGATTTCGACTACGCGTTCAATCTCGGCTAC
GGCCGGCGCTATACCGATGCCGCGCCGCTGTTCAGTGCGATCCGCGACATCGTCGACGCCGATACGCAACGCCGGATCGA
CGCGGCCGGGCAGCGCGCGTAA

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20221.17 Da        Isoelectric Point: 11.0866

>AT106738 WP_111018693.1 NZ_CP029825:1010851-1011408 [Burkholderia sp. JP2-270]
MTASPLHTPPLGPQLKRWRALHRVKQSHAAELFGVAQSTISRWEAGIQQMSPDERATAERLLAARLDSAGDHALARLITG
SAGRMHLVCDLTHRLLASSPARAAEFSQPLPILLGTSLWRYATPEIVRMEAALDTLGWRDRAGPPSVEFDTGANASRVVP
IRGSRCRWTRMTLSDGSAARLVETL

Download         Length: 558 bp

>AT106738 NZ_CP029825:1010851-1011408 [Burkholderia sp. JP2-270]
ATGACCGCCTCACCGCTTCACACGCCACCACTAGGCCCACAGCTCAAGCGCTGGCGCGCGCTGCACCGCGTGAAGCAAAG
CCACGCCGCCGAGCTGTTCGGCGTCGCGCAATCGACGATCTCCCGCTGGGAAGCCGGCATCCAGCAGATGTCGCCCGACG
AGCGCGCGACGGCCGAGCGGCTGCTCGCCGCGCGCCTCGATTCCGCGGGCGACCACGCGCTTGCGCGGCTCATCACGGGC
AGCGCGGGCCGCATGCATCTCGTGTGCGACCTCACGCACCGCCTGCTCGCCAGTTCGCCGGCGCGCGCGGCCGAGTTCTC
GCAGCCGCTGCCGATACTGCTCGGCACGTCGCTGTGGCGCTACGCGACGCCGGAGATCGTGCGCATGGAAGCCGCGCTCG
ACACGCTCGGCTGGCGCGACCGCGCGGGGCCGCCGAGCGTCGAATTCGACACCGGCGCGAATGCATCGCGCGTCGTGCCG
ATTCGCGGCAGCAGGTGCCGGTGGACGCGGATGACGCTGTCGGACGGTTCGGCCGCGCGGCTGGTGGAAACGCTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References