Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 486988..487565 Replicon chromosome
Accession NZ_CP029825
Organism Burkholderia sp. JP2-270

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag DM992_RS19835 Protein ID WP_111018298.1
Coordinates 487200..487565 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag DM992_RS19830 Protein ID WP_111018297.1
Coordinates 486988..487206 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DM992_RS19810 482835..484085 - 1251 WP_111018294.1 Zn-dependent hydrolase -
DM992_RS19815 484078..484602 - 525 WP_111018295.1 L-2-amino-thiazoline-4-carboxylic acid hydrolase -
DM992_RS19820 484621..485787 - 1167 WP_111018296.1 branched-chain amino acid ABC transporter substrate-binding protein -
DM992_RS19825 485965..486861 + 897 WP_072436531.1 LysR family transcriptional regulator -
DM992_RS19830 486988..487206 + 219 WP_111018297.1 CopG family transcriptional regulator Antitoxin
DM992_RS19835 487200..487565 + 366 WP_111018298.1 type II toxin-antitoxin system VapC family toxin Toxin
DM992_RS19840 487665..488018 - 354 WP_111018299.1 GNAT family N-acetyltransferase -
DM992_RS19845 488327..488890 + 564 WP_034179823.1 peroxiredoxin -
DM992_RS19850 489008..490606 + 1599 WP_111018300.1 alkyl hydroperoxide reductase subunit F -
DM992_RS19855 491134..491880 - 747 WP_111018301.1 MipA/OmpV family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-106)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-40)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13551.64 Da        Isoelectric Point: 9.5275

>T106737 WP_111018298.1 NZ_CP029825:487200-487565 [Burkholderia sp. JP2-270]
MVKALFDTNILIDYLGGVESARAELGRYDYRAISTISWMEVLVGTSARNEAPTRAWLSSFDVIALDSTVANRAVIIRKER
RIRLPDAIVWASAQVNGLLLVSRNTKDFPPTEPGIRMPYQI

Download         Length: 366 bp

>T106737 NZ_CP029825:487200-487565 [Burkholderia sp. JP2-270]
ATGGTAAAAGCTCTCTTCGACACCAACATCCTGATCGACTATCTGGGTGGCGTGGAATCCGCCCGCGCGGAGCTAGGCCG
CTATGACTATCGTGCGATCAGCACGATCTCGTGGATGGAGGTTCTGGTCGGCACGTCCGCACGTAACGAAGCGCCGACTC
GCGCATGGCTCTCGTCATTCGATGTCATCGCGCTCGACAGCACGGTGGCGAATCGTGCGGTGATCATTCGCAAGGAACGC
CGCATACGCCTGCCTGACGCGATCGTCTGGGCATCGGCGCAAGTGAACGGGCTGCTGCTCGTGTCGCGCAACACGAAAGA
CTTCCCTCCCACCGAACCCGGCATTCGAATGCCGTATCAGATCTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8312.51 Da        Isoelectric Point: 4.7683

>AT106737 WP_111018297.1 NZ_CP029825:486988-487206 [Burkholderia sp. JP2-270]
MSRILVDLSDGQLDELAVIVKTERRPRAAIIRDAIDAYIALHKRPLADDVFGLWKDRTVDGLAYQEEMRSEW

Download         Length: 219 bp

>AT106737 NZ_CP029825:486988-487206 [Burkholderia sp. JP2-270]
ATGAGCCGAATTCTGGTTGATCTGTCGGATGGCCAGCTCGACGAGTTGGCCGTCATCGTCAAGACTGAACGTCGTCCCCG
CGCCGCGATCATCCGCGACGCGATTGATGCCTACATTGCCCTGCACAAGCGCCCGCTCGCCGACGACGTATTCGGCCTCT
GGAAAGATCGCACGGTCGACGGGCTCGCGTATCAGGAGGAAATGCGCTCGGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References