Detailed information of TA system TA106736

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-MazE
• Location: 148252..148885
• Replicon: chromosome
• Accession: NZ_CP029825
• Organism: Burkholderia sp. JP2-270

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: DM992_RS18315
• Protein ID: WP_111018061.1
• Coordinates: 148252..148665 (-)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A4V8GBN8
• Locus tag: DM992_RS18320
• Protein ID: WP_044843105.1
• Coordinates: 148652..148885 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DM992_RS18300	144519..145826	+	1308	WP_111018058.1	shikimate transporter	-
DM992_RS18305	146028..147329	+	1302	WP_111018059.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
DM992_RS18310	147458..148069	-	612	WP_111018060.1	hypothetical protein	-
DM992_RS18315	148252..148665	-	414	WP_111018061.1	PIN domain-containing protein	Toxin
DM992_RS18320	148652..148885	-	234	WP_044843105.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
DM992_RS18325	149043..149813	+	771	WP_072436791.1	helix-turn-helix domain-containing protein	-
DM992_RS18330	149910..152210	-	2301	WP_111020281.1	ATP-dependent DNA helicase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (10-119)

Antitoxin

• SpoVT-AbrB domain (5-37)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 15135.34 Da
• Isoelectric Point: 5.9777

>T106736 WP_111018061.1 NZ_CP029825:c148665-148252 [Burkholderia sp. JP2-270]
MSGIEPAKSFVDSNVVLYLLSADETKANRAEALFLRRPTVSVQVLNEVAGVCSRKLRMPWSDVAQFLEPIRSLCHVVPVT
IDTHDLARRLAERHGLSFHDACIVAAASLEGCEYLYTEDMHDGLRVDGGPVLRNPFA

Nucleotide

• Length: 414 bp

>T106736 NZ_CP029825:c148665-148252 [Burkholderia sp. JP2-270]
ATGAGCGGGATTGAGCCGGCGAAATCGTTCGTCGACAGCAATGTCGTGCTTTATCTGCTGTCCGCGGACGAAACCAAGGC
GAATCGGGCGGAGGCACTGTTCCTTCGGCGGCCTACCGTCAGTGTCCAGGTACTGAACGAGGTCGCCGGCGTCTGCAGCC
GAAAATTGCGGATGCCGTGGAGCGATGTGGCGCAGTTTCTGGAACCGATCAGGAGCTTGTGCCATGTCGTACCGGTCACG
ATCGATACGCATGACCTGGCGCGAAGGCTCGCGGAGCGGCATGGCCTGTCCTTCCATGACGCGTGCATCGTCGCCGCCGC
GTCGCTCGAGGGCTGCGAGTACCTGTACACCGAGGACATGCACGACGGCCTGCGCGTGGACGGCGGTCCGGTGCTGCGCA
ATCCGTTCGCCTGA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8904.18 Da
• Isoelectric Point: 10.2811

>AT106736 WP_044843105.1 NZ_CP029825:c148885-148652 [Burkholderia sp. JP2-270]
MQVAKWGNSLAVRLPASVVDALELREGDDIEIVVDSPRVFAVRRKPRPDELLQRLRRFRGKLPADFKFSRDDANERD

Nucleotide

• Length: 234 bp

>AT106736 NZ_CP029825:c148885-148652 [Burkholderia sp. JP2-270]
ATGCAGGTCGCAAAGTGGGGCAATAGCCTGGCCGTCCGCCTTCCCGCCAGTGTGGTCGATGCACTGGAGCTCCGCGAAGG
GGACGATATCGAGATCGTGGTCGATAGCCCGCGCGTGTTTGCCGTCCGCCGCAAGCCGAGACCCGACGAACTTCTGCAAC
GGTTGCGGCGTTTCAGGGGCAAGCTGCCCGCCGATTTCAAGTTCAGCCGGGACGATGCGAATGAGCGGGATTGA

Structures

Antitoxin

• AlphaFold DB: A0A4V8GBN8