Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 2735747..2736423 Replicon chromosome
Accession NZ_CP029824
Organism Burkholderia sp. JP2-270

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag DM992_RS12945 Protein ID WP_111017106.1
Coordinates 2735747..2736163 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag DM992_RS12950 Protein ID WP_111017911.1
Coordinates 2736160..2736423 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DM992_RS12920 2731557..2731911 - 355 Protein_2458 type II toxin-antitoxin system RelE/ParE family toxin -
DM992_RS12925 2731904..2732146 - 243 Protein_2459 type II toxin-antitoxin system ParD family antitoxin -
DM992_RS12930 2732245..2733408 - 1164 WP_111017104.1 amidohydrolase -
DM992_RS12935 2733751..2734824 + 1074 WP_111017910.1 hypothetical protein -
DM992_RS12940 2734793..2735698 + 906 WP_111017105.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
DM992_RS12945 2735747..2736163 - 417 WP_111017106.1 PIN domain-containing protein Toxin
DM992_RS12950 2736160..2736423 - 264 WP_111017911.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
DM992_RS12955 2736676..2737695 - 1020 WP_111017912.1 acetyltransferase -
DM992_RS12960 2737695..2738534 - 840 WP_111017913.1 N(5)-hydroxyornithine transformylase PvdF -
DM992_RS12965 2738621..2740921 - 2301 WP_111017107.1 TonB-dependent siderophore receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-130)

Antitoxin

SpoVT-AbrB domain

(7-53)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14616.83 Da        Isoelectric Point: 8.5394

>T106735 WP_111017106.1 NZ_CP029824:c2736163-2735747 [Burkholderia sp. JP2-270]
VTTLYMLDTNICSFIMRERPPVVLSRLQSCVNARHRIVVSAITYAEMRFVAVGRKASPKHAELVTAFVSRLDGVLPWDTA
AVDATAAIRADLAARGTPIGANDASIAGHAIAAGAVLVTNNGREFGRVAGLSLEDWAA

Download         Length: 417 bp

>T106735 NZ_CP029824:c2736163-2735747 [Burkholderia sp. JP2-270]
GTGACCACGCTCTACATGCTCGATACGAATATCTGTTCGTTCATCATGCGCGAGCGGCCGCCGGTGGTGCTGTCGCGGTT
GCAGTCGTGCGTCAACGCTCGGCACCGGATCGTCGTGTCGGCGATCACCTATGCCGAAATGCGGTTCGTGGCCGTGGGCA
GGAAGGCGTCGCCGAAGCATGCGGAACTCGTGACGGCGTTTGTTTCGCGGCTGGATGGCGTGCTGCCGTGGGATACGGCG
GCCGTCGACGCAACGGCCGCGATTCGCGCGGATCTCGCCGCGCGAGGCACGCCGATCGGCGCGAACGATGCGTCGATCGC
CGGGCATGCGATCGCGGCCGGCGCGGTGCTCGTCACGAACAACGGGCGGGAGTTCGGCCGTGTCGCCGGGTTGTCGCTCG
AAGACTGGGCGGCCTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9789.04 Da        Isoelectric Point: 4.5230

>AT106735 WP_111017911.1 NZ_CP029824:c2736423-2736160 [Burkholderia sp. JP2-270]
MRTVSIFKNARNQAIRIPKDMEFEGVTELEIRREGDTLLLRPVRPTWLSFANEPLADAEFLAERPAVIESGRFDLSGDAD
APTESGR

Download         Length: 264 bp

>AT106735 NZ_CP029824:c2736423-2736160 [Burkholderia sp. JP2-270]
ATGCGCACCGTTTCCATTTTCAAGAACGCCCGTAACCAGGCAATCCGCATCCCGAAGGACATGGAGTTCGAGGGGGTGAC
GGAACTCGAGATCCGCCGCGAGGGCGACACGCTGCTGCTGCGCCCCGTGCGCCCCACGTGGCTCTCGTTCGCGAACGAAC
CGCTGGCCGACGCCGAATTCCTCGCCGAACGCCCGGCCGTCATCGAGTCCGGCCGCTTCGACCTGTCCGGCGACGCCGAC
GCGCCGACGGAGTCCGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References